Graves' Disease after mRNA COVID-19 Vaccination, with the Presence of Autoimmune Antibodies Even One Year Later

被引：8

作者：

Nakamura, Fuminori ^{[1
]}

Awaya, Toru ^{[1
]}

Ohira, Masahiro ^{[2
]}

Enomoto, Yoshinari ^{[1
]}

Moroi, Masao ^{[1
]}

Nakamura, Masato ^{[1
]}

机构：

[1] Toho Univ, Dept Cardiovasc Med, Ohashi Med Ctr, 2-22-36 Ohashi,Meguro Ku, Tokyo 1538515, Japan

[2] Toho Univ, Dept Diabet Metab & Endocrinol, Ohashi Med Ctr, Tokyo 1538515, Japan

来源：

VACCINES | 2023年 / 11卷 / 05期

关键词：

ASIA; cross-reactivity; Graves' disease; mRNA COVID-19 vaccination; DIAGNOSIS; TRAB;

D O I：

10.3390/vaccines11050934

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 45-year-old man who had received his second mRNA COVID-19 vaccination one week earlier was presented to the emergency department with chest discomfort. Therefore, we suspected post-vaccination myocarditis; however, the patient showed no signs of myocarditis. After 2 weeks, he revisited the hospital complaining of palpitations, hand tremors, and weight loss. The patient exhibited high free thyroxine (FT4) (6.42 ng/dL), low thyroid-stimulating hormone (TSH) (< 0.01 mu IU/mL), and high TSH receptor antibody (17.5 IU/L) levels, and was diagnosed with Graves' disease. Thiamazole was administered, and the patient's FT4 levels normalized after 30 days. One year later, the patient's FT4 is stable; however, their TSH receptor antibodies have not become negative and thiamazole has continued. This is the first case report to follow the course of Graves' disease one year after mRNA COVID-19 vaccination.

引用

页数：8

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