Long-term mepolizumab treatment reduces relapse rates in super-responders with eosinophilic granulomatosis with polyangiitis

被引：7

作者：

Masumoto, Nami ^{[1
,2
]}

Oshikata, Chiyako ^{[1
,2
,3
]}

Nakadegawa, Ryo ^{[1
]}

Motobayashi, Yuto ^{[1
]}

Osada, Reeko ^{[1
]}

Manabe, Saki ^{[1
]}

Kaneko, Takeshi ^{[2
]}

Tsurikisawa, Naomi ^{[1
,2
,3
]}

机构：

[1] Natl Hosp Org Yokohama Med Ctr, Dept Respirol, 3-60-2 Harajuku, Totsuka Ku, Yokohama 2458575, Japan

[2] Yokohama City Univ Grad Sch Med, Dept Pulmonol, 3-9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[3] Hiratsuka City Hosp, Dept Allergy & Respirol, 1-19-1 Minamihara, Hiratsuka, Kanagawa 2540065, Japan

来源：

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY | 2023年 / 19卷 / 01期

关键词：

Churg-Strauss syndrome; Eosinophilic granulomatosis with polyangiitis; Intravenous immunoglobulin; Mepolizumab; Systemic vasculitis; CHURG-STRAUSS-SYNDROME; REGULATORY T-CELLS; MONOCLONAL-ANTIBODY; SEVERE ASTHMA; FOLLOW-UP; INTERLEUKIN-5; PHARMACOKINETICS; PHARMACODYNAMICS; MAINTENANCE; INCREASES;

D O I：

10.1186/s13223-023-00801-7

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BackgroundThe mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunosuppressive agents, and biologics. Mepolizumab, an anti-interleukin-5 monoclonal antibody, induces remission and decreases the daily corticosteroid dose; however, the clinical efficacy of mepolizumab in EGPA and the prognosis with long-term treatment with this drug are unknown.MethodsSeventy-one EGPA patients were treated at Hiratsuka City Hospital, Japan, between April 2018 and March 2022. We administered mepolizumab for a mean of 2.8 +/- 1.7 years to 43 patients in whom remission could not be induced by conventional treatment. After excluding 18 patients who had received mepolizumab for less than 3 years, we classified 15 patients into a "super-responder group" (the daily dose of corticosteroids or other immunosuppressant could be decreased, or the interval between IVIG treatments could be prolonged) and 10 patients into a "responder group" (neither of these changes was achievable). Eosinophil numbers, serum IgG levels, daily doses of corticosteroids and other immunosuppressants, Birmingham Vasculitis Activity Score (BVAS), and relapse frequency before and after mepolizumab initiation were determined.ResultsBlood eosinophil count at diagnosis and the lowest serum IgG level before mepolizumab treatment were significantly higher in super-responders than in responders (p < 0.05). In super-responders, the prednisolone dose at last visit on mepolizumab treatment was lower than that before treatment (p < 0.01) and lower than that at last visit in the responders (p < 0.01). In both groups, peripheral blood eosinophil numbers and BVAS were lower after starting mepolizumab than before (p < 0.01). BVAS before mepolizumab (p < 0.05) and at last visit (p < 0.01) were lower in super-responders than in responders. Relapse rates every year after the start of mepolizumab were lower in super-responders than in responder groups (p < 0.01). In super-responders, relapse rates were lower during the 3 years following mepolizumab initiation (p < 0.01) and at last visit (p < 0.01) were significantly lower than after 1 year of treatment.ConclusionMepolizumab treatment of super-responders sustainably reduced the relapse rate.

引用

页数：14