Anti-tumor effects of miR-34a by regulating immune cells in the tumor microenvironment

被引：15

作者：

Yin, Man ^{[1
]}

Zhang, Zhiqiang ^{[1
]}

Wang, Yunfei ^{[2
,3
]}

机构：

[1] Jining Med Univ, Dept Clin Med, Jining 272000, Shandong, Peoples R China

[2] Jining Med Univ, Affiliated Hosp, Dept Gynecol, Jining 272029, Shandong, Peoples R China

[3] Jining Med Univ, Affiliated Hosp, Dept Gynecol, Gu Huai Rd 89, Jining 272029, Shandong, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 10期

基金：

中国国家自然科学基金;

关键词：

antitumor; immunotherapy; miR-34a; tumor immune microenvironment; GASTRIC-CANCER; NEOADJUVANT CHEMOTHERAPY; GENE-EXPRESSION; T-CELLS; MICRORNAS; THERAPY; TARGETS; GROWTH; P53; PROLIFERATION;

D O I：

10.1002/cam4.5826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant tumors pose a serious threat to human health. The development of malignant tumors is characterized by uncontrolled cell division and immune evasion. The micro-ribonucleic acid-34a (miR-34a) is a small noncoding single-stranded ribonucleic acid that is ubiquitously present in normal human tissues. However, it has been confirmed to be dysregulated in a variety of tumor cells. Numerous research have revealed the importance of miR-34a in the treatment of various malignancies. MiR-34a deletion can hasten the growth of tumors whereas miR-34a overexpression suppresses the proliferation, invasion, and migration of cancer cells. Moreover, more recent studies have highlighted its role in immunity and investigated its applicability to particular tumors. Through various immune cells, factors, and other mechanisms, miR-34a can inhibit tumor carcinogenesis. In view of the important role of miR-34a in tumors, this research reviewed the aspects of miR-34a regulation of tumor immune microenvironment to exert anti-tumor effects in order to clarify the potential immunotherapy value of miR-34a in tumors.

引用

页码：11602 / 11610

页数：9

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