Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

被引：3

作者：

Mao, Ziling ^{[1
,2
]}

Baker, Jacqueline Roshelli ^{[1
]}

Takeuchi, Masayoshi ^{[3
]}

Hyogo, Hideyuki ^{[4
,5
]}

Tjonneland, Anne ^{[6
,7
]}

Eriksen, Anne Kirstine ^{[6
]}

Severi, Gianluca ^{[8
,9
]}

Rothwell, Joseph ^{[8
]}

Laouali, Nasser ^{[8
]}

Katzke, Verena ^{[10
]}

Kaaks, Rudolf ^{[10
]}

Schulze, Matthias B. ^{[11
,12
]}

Palli, Domenico ^{[13
]}

Sieri, Sabina ^{[14
]}

de Magistris, Maria Santucci ^{[15
]}

Tumino, Rosario ^{[16
]}

Sacerdote, Carlotta ^{[17
]}

Derksen, Jeroen W. G. ^{[18
]}

Gram, Inger T. ^{[19
]}

Skeie, Guri ^{[19
]}

Sandanger, Torkjel M. ^{[19
]}

Quiros, Jose Ramon ^{[20
]}

Crous-Bou, Marta ^{[21
,22
]}

Sanchez, Maria-Jose ^{[23
,24
,25
,26
]}

Amiano, Pilar ^{[25
,27
,28
]}

Colorado-Yohar, Sandra M. ^{[25
,29
,30
]}

Guevara, Marcela ^{[25
,31
,32
]}

Harlid, Sophia ^{[33
]}

Johansson, Ingegerd ^{[34
]}

Perez-Cornago, Aurora ^{[35
]}

Freisling, Heinz ^{[36
]}

Gunter, Marc ^{[36
]}

Weiderpass, Elisabete ^{[37
]}

Heath, Alicia K. ^{[38
]}

Aglago, Elom ^{[38
]}

Jenab, Mazda ^{[36
]}

Fedirko, Veronika ^{[1
,39
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[3] Kanazawa Med Univ, Med Res Inst, Dept Adv Med, Kanazawa, Ishikawa, Japan

[4] Hiroshima Univ Hosp, Dept Gastroenterol & Metab, Hiroshima, Japan

[5] Lifecare Clin Hiroshima, Hiroshima, Japan

[6] Danish Canc Soc Res Ctr, Diet Canc & Hlth, Copenhagen, Denmark

[7] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[8] Univ Paris Saclay, Exposome & Hered Team, Ctr Epidemiol & Populat Hlth, UVSQ,Inserm,U1018, Villejuif, France

[9] G Parenti Univ Florence, Dept Stat, Comp Sci Applicat, Florence, Italy

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[12] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[13] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[14] Fdn IRCCS, Epidemiol & Prevent Unit, Ist Nazl Tumori Milano Via Venezian, Milan, Italy

[15] Azienda Osped Univ Federico II, Naples, Italy

[16] AIRE ONLUS, Hyblean Assoc Epidemiol Res, Ragusa, Italy

[17] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[18] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] UiT The Arctic Univ Norway, Dept Community Med, Tromso, Norway

[20] Publ Hlth Directorate, Asturias, Spain

[21] Bellvitge Biomed Res Inst IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona, Spain

[22] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[23] Escuela Andaluza Salud Publ, Granada, Spain

[24] Inst Invest Biosanitaria Ibs Granada, Granada, Spain

[25] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[26] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[27] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[28] Biodonostia Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain

[29] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[30] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[31] Navarra Publ Hlth Inst, Pamplona, Spain

[32] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[33] Umea Univ, Dept Radiat Sci, Umea, Sweden

[34] Umea Univ, Dept Odontol, Umea, Sweden

[35] Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Canc Epidemiol Unit, Oxford, England

[36] World Hlth Org IARC WHO, Sect Nutr & Metab, Nutr Epidemiol Grp, Int Agcy Res Canc, Lyon, France

[37] Int Agcy Res Canc IARC WHO, Off Director, Lyon, France

[38] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[39] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2023年 / 152卷 / 11期

关键词：

advanced glycation end products; colorectal cancer; glyceraldehyde-derived advanced glycation end products; mortality; prospective study; TOXIC AGES TAGE; METABOLIC SYNDROME; RECEPTOR; INFLAMMATION; ASSOCIATION; GROWTH; CELLS; COMPLICATIONS; INDIVIDUALS; INVOLVEMENT;

D O I：

10.1002/ijc.34449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, P-trend = .002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, P-trend < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; P-effect modification = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

引用

页码：2257 / 2268

页数：12

共 57 条

[11] Microbiota disbiosis is associated with colorectal cancer
Gao, Zhiguang
Guo, Bomin
Gao, Renyuan
Zhu, Qingchao
Qin, Huanlong
[J]. FRONTIERS IN MICROBIOLOGY, 2015, 6
[12] Comparing smoothing techniques in Cox models for exposure-response relationships
Govindarajulu, Usha S.
Spiegelman, Donna
Thurston, Sally W.
Ganguli, Bhaswati
Eisen, Ellen A.
[J]. STATISTICS IN MEDICINE, 2007, 26 (20) : 3735 - 3752
[13] Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases
Grillo, M. A.
Colombatto, S.
[J]. AMINO ACIDS, 2008, 35 (01) : 29 - 36
[14] Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)
Guercio, Brendan J.
Zhang, Sui
Niedzwiecki, Donna
Li, Yanping
Babic, Ana
Morales-Oyarvide, Vicente
Saltz, Leonard B.
Mayer, Robert J.
Mowat, Rex B.
Whittom, Renaud
Hantel, Alexander
Benson, Al
Atienza, Daniel
Messino, Michael
Kindler, Hedy
Venook, Alan
Ogino, Shuji
Zoltick, Emilie S.
Stampfer, Meir
Ng, Kimmie
Wu, Kana
Willett, Walter C.
Giovannucci, Edward L.
Meyerhardt, Jeffrey A.
Fuchs, Charles S.
[J]. PLOS ONE, 2018, 13 (07):
[15] International Agency for Research on Cancer (Lyon), 2020, GLOBAL CANC OBSERVAT
[16] Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Growth and VEGF Expression in MCF-7 Breast Cancer Cells by Suppressing AGEs Receptor Expression via AMP-activated Protein Kinase
Ishibashi, Y.
Matsui, T.
Takeuchi, M.
Yamagishi, S.
[J]. HORMONE AND METABOLIC RESEARCH, 2013, 45 (05) : 387 - 390
[17] Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.21492, 10.3322/caac.20115]
[18] Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology
Jinno, Masao
Takeuchi, Masayoshi
Watanabe, Aiko
Teruya, Koji
Hirohama, Jun
Eguchi, Noriko
Miyazaki, Aiko
[J]. HUMAN REPRODUCTION, 2011, 26 (03) : 604 - 610
[19] The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk
Kong, So Yeon
Takeuchi, Masayoshi
Hyogo, Hideyuki
McKeown-Eyssen, Gail
Yamagishi, Sho-Ichi
Chayama, Kazuaki
O'Brien, Peter J.
Ferrari, Pietro
Overvad, Kim
Olsen, Anja
Tjonneland, Anne
Boutron-Ruault, Marie-Christine
Bastide, Nadia
Carbonnel, Franck
Kuehn, Tilman
Kaaks, Rudolf
Boeing, Heiner
Aleksandrova, Krasimira
Trichopoulou, Antonia
Lagiou, Pagona
Vasilopoulou, Effie
Masala, Giovanna
Pala, Valeria
De Magistris, Maria Santucci
Tumino, Rosario
Naccarati, Alessio
Bueno-De-Mesquita, H. B.
Peeters, Petra H.
Weiderpass, Elisabete
Quiros, J. Ramon
Jakszyn, Paula
Sanchez, Maria-Jose
Dorronsoro, Miren
Gavrila, Diana
Ardanaz, Eva
Rutegard, Martin
Nystroem, Hanna
Wareham, Nicholas J.
Khaw, Kay-Tee
Bradbury, Kathryn E.
Romieu, Isabelle
Freisling, Heinz
Stavropoulou, Faidra
Gunter, Marc J.
Cross, Amanda J.
Riboli, Elio
Jenab, Mazda
Bruce, W. Robert
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015, 24 (12) : 1855 - 1863
[20] Peterson LL, 2020, J CLIN ONCOL, V38

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