Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

被引：3

作者：

Mao, Ziling ^{[1
,2
]}

Baker, Jacqueline Roshelli ^{[1
]}

Takeuchi, Masayoshi ^{[3
]}

Hyogo, Hideyuki ^{[4
,5
]}

Tjonneland, Anne ^{[6
,7
]}

Eriksen, Anne Kirstine ^{[6
]}

Severi, Gianluca ^{[8
,9
]}

Rothwell, Joseph ^{[8
]}

Laouali, Nasser ^{[8
]}

Katzke, Verena ^{[10
]}

Kaaks, Rudolf ^{[10
]}

Schulze, Matthias B. ^{[11
,12
]}

Palli, Domenico ^{[13
]}

Sieri, Sabina ^{[14
]}

de Magistris, Maria Santucci ^{[15
]}

Tumino, Rosario ^{[16
]}

Sacerdote, Carlotta ^{[17
]}

Derksen, Jeroen W. G. ^{[18
]}

Gram, Inger T. ^{[19
]}

Skeie, Guri ^{[19
]}

Sandanger, Torkjel M. ^{[19
]}

Quiros, Jose Ramon ^{[20
]}

Crous-Bou, Marta ^{[21
,22
]}

Sanchez, Maria-Jose ^{[23
,24
,25
,26
]}

Amiano, Pilar ^{[25
,27
,28
]}

Colorado-Yohar, Sandra M. ^{[25
,29
,30
]}

Guevara, Marcela ^{[25
,31
,32
]}

Harlid, Sophia ^{[33
]}

Johansson, Ingegerd ^{[34
]}

Perez-Cornago, Aurora ^{[35
]}

Freisling, Heinz ^{[36
]}

Gunter, Marc ^{[36
]}

Weiderpass, Elisabete ^{[37
]}

Heath, Alicia K. ^{[38
]}

Aglago, Elom ^{[38
]}

Jenab, Mazda ^{[36
]}

Fedirko, Veronika ^{[1
,39
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[3] Kanazawa Med Univ, Med Res Inst, Dept Adv Med, Kanazawa, Ishikawa, Japan

[4] Hiroshima Univ Hosp, Dept Gastroenterol & Metab, Hiroshima, Japan

[5] Lifecare Clin Hiroshima, Hiroshima, Japan

[6] Danish Canc Soc Res Ctr, Diet Canc & Hlth, Copenhagen, Denmark

[7] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[8] Univ Paris Saclay, Exposome & Hered Team, Ctr Epidemiol & Populat Hlth, UVSQ,Inserm,U1018, Villejuif, France

[9] G Parenti Univ Florence, Dept Stat, Comp Sci Applicat, Florence, Italy

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[12] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[13] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[14] Fdn IRCCS, Epidemiol & Prevent Unit, Ist Nazl Tumori Milano Via Venezian, Milan, Italy

[15] Azienda Osped Univ Federico II, Naples, Italy

[16] AIRE ONLUS, Hyblean Assoc Epidemiol Res, Ragusa, Italy

[17] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[18] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] UiT The Arctic Univ Norway, Dept Community Med, Tromso, Norway

[20] Publ Hlth Directorate, Asturias, Spain

[21] Bellvitge Biomed Res Inst IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona, Spain

[22] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[23] Escuela Andaluza Salud Publ, Granada, Spain

[24] Inst Invest Biosanitaria Ibs Granada, Granada, Spain

[25] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[26] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[27] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[28] Biodonostia Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain

[29] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[30] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[31] Navarra Publ Hlth Inst, Pamplona, Spain

[32] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[33] Umea Univ, Dept Radiat Sci, Umea, Sweden

[34] Umea Univ, Dept Odontol, Umea, Sweden

[35] Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Canc Epidemiol Unit, Oxford, England

[36] World Hlth Org IARC WHO, Sect Nutr & Metab, Nutr Epidemiol Grp, Int Agcy Res Canc, Lyon, France

[37] Int Agcy Res Canc IARC WHO, Off Director, Lyon, France

[38] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[39] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2023年 / 152卷 / 11期

关键词：

advanced glycation end products; colorectal cancer; glyceraldehyde-derived advanced glycation end products; mortality; prospective study; TOXIC AGES TAGE; METABOLIC SYNDROME; RECEPTOR; INFLAMMATION; ASSOCIATION; GROWTH; CELLS; COMPLICATIONS; INDIVIDUALS; INVOLVEMENT;

D O I：

10.1002/ijc.34449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, P-trend = .002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, P-trend < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; P-effect modification = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

引用

页码：2257 / 2268

页数：12

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