Does initial skeletal muscle size or sex affect the magnitude of muscle loss in response to 14 days immobilization?

被引：2

作者：

Coffey, Vernon G. ^{[1
,2
]}

McGlory, Chris ^{[3
,4
]}

Phillips, Stuart M. ^{[5
]}

Doering, Thomas M. ^{[6
]}

机构：

[1] Bond Univ, Bond Inst Hlth & Sport, Gold Coast, Qld, Australia

[2] Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld, Australia

[3] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada

[4] Queens Univ, Dept Med, Kingston, ON, Canada

[5] McMaster Univ, Dept Kinesiol, Exercise Metab Res Grp, Hamilton, ON, Canada

[6] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld, Australia

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2023年 / 48卷 / 05期

基金：

加拿大健康研究院;

关键词：

atrophy; fat-free mass; cross sectional area; ATROPHY;

D O I：

10.1139/apnm-2022-0458

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We aimed to determine whether there was a relationship between pre-immobilization skeletal muscle size and the mag-nitude of muscle atrophy following 14 days of unilateral lower limb immobilization. Our findings (n = 30) show that pre -immobilization leg fat-free mass and quadriceps cross-sectional area (CSA) were unrelated to the magnitude of muscle atrophy. However, sex-based differences may be present, but confirmatory work is required. In women, pre-immobilization leg fat-free mass and CSA were associated with changes in quadriceps CSA after immobilization (n = 9, r2 = 0.54-0.68; P < 0.05). The extent of muscle atrophy is not affected by initial muscle mass, but there is potential for sex-based differences.

引用

页码：411 / 416

页数：6