Copper-Catalyzed Dynamic Kinetic Resolution of Secondary Phosphine Oxides

被引：20
作者：
Liu, Baixue [1 ,2 ]
Liu, Peng [2 ,3 ]
Wang, Xue [1 ,2 ]
Feng, Feng [1 ,2 ]
Wang, Zhen [1 ,2 ]
Yang, Wenqiang [1 ,2 ]
机构：
[1] Linyi Univ, Coll Med, Linyi 276000, Shandong, Peoples R China
[2] Linyi Univ, Coll Chem & Chem Engn, Linyi 276000, Shandong, Peoples R China
[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth GIBH, Guangzhou 510530, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 13期
基金：
中国国家自然科学基金;
关键词：
P-STEREOGENIC PHOSPHINES; ENANTIOSELECTIVE SYNTHESIS; ARYLATION;
D O I：
10.1021/acs.orglett.3c00099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed dynamic kinetic resolution of secondary phosphine oxides has been successfully developed, providing a general method for the gram-scale enantioselective synthesis of P-stereogenic cyclic phosphine oxides with high yields and high enantioselectivities. The products could be easily reduced to the corresponding useful P(III)-stereogenic cyclic phosphines. A mechanism of the dynamic kinetic resolution involving the unusual rapid racemization of SPOs has been proposed.
引用
收藏
页码：2178 / 2183
页数：6
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