Differences in Striatal Metabolism in [18F]FDG PET in Parkinson's Disease and Atypical Parkinsonism

被引：9

作者：

Seiffert, Alexander P. ^{[1
]}

Gomez-Grande, Adolfo ^{[2
,3
]}

Alonso-Gomez, Laura ^{[1
]}

Mendez-Guerrero, Antonio ^{[4
]}

Villarejo-Galende, Alberto ^{[3
,4
,5
,6
]}

Gomez, Enrique J. ^{[1
,7
]}

Sanchez-Gonzalez, Patricia ^{[1
,7
]}

机构：

[1] Univ Politecn Madrid, Biomed Engn & Telemed Ctr, Ctr Biomed Technol, ETSI Telecomunicac, Madrid 28040, Spain

[2] Hosp Univ 12 Octubre, Dept Nucl Med, Madrid 28041, Spain

[3] Univ Complutense Madrid, Fac Med, Madrid 28040, Spain

[4] Hosp Univ 12 Octubre, Dept Neurol, Madrid 28041, Spain

[5] Hosp 12 Octubre Res Inst Imas12, Grp Neurodegenerat Dis, Madrid 28041, Spain

[6] Biomed Res Networking Ctr Neurodegenerat Dis CIBE, Madrid 28029, Spain

[7] Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Madrid 28029, Spain

来源：

DIAGNOSTICS | 2023年 / 13卷 / 01期

关键词：

neuroimaging; F-18]FDG PET; neurodegenerative diseases; Parkinson's disease; atypical parkinsonism; striatum; DIAGNOSIS; PATTERNS; LEVODOPA; SPECT;

D O I：

10.3390/diagnostics13010006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurodegenerative parkinsonisms affect mainly cognitive and motor functions and are syndromes of overlapping symptoms and clinical manifestations such as tremor, rigidness, and bradykinesia. These include idiopathic Parkinson's disease (PD) and the atypical parkinsonisms, namely progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA) and dementia with Lewy body (DLB). Differences in the striatal metabolism among these syndromes are evaluated using [F-18]FDG PET, caused by alterations to the dopaminergic activity and neuronal loss. A study cohort of three patients with PD, 29 with atypical parkinsonism (10 PSP, 6 CBD, 2 MSA, 7 DLB, and 4 non-classifiable), and a control group of 25 patients with normal striatal metabolism is available. Standardized uptake value ratios (SUVR) are extracted from the striatum, and the caudate and the putamen separately. SUVRs are compared among the study groups. In addition, hemispherical and caudate-putamen differences are evaluated in atypical parkinsonisms. Striatal hypermetabolism is detected in patients with PD, while atypical parkinsonisms show hypometabolism, compared to the control group. Hemispherical differences are observed in CBD, MSA and DLB, with the latter also showing statistically significant caudate-putamen asymmetry (p = 0.018). These results indicate disease-specific metabolic uptake patterns in the striatum that can support the differential diagnosis.

引用

页数：10

共 36 条

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