Beneficial Effect of Upadacitinib in an Adult Patient with Juvenile Idiopathic Arthritis-associated Uveitis after Unsatisfactory Response to Tofacitinib: A Case Report

被引：14

作者：

Baquet-Walscheid, Karoline ^{[1
,2
]}

Heinz, Carsten ^{[1
,2
]}

Rath, Thomas ^{[3
]}

Scheel, Martin ^{[4
]}

Heiligenhaus, Arnd ^{[1
,2
]}

机构：

[1] St Franziskus Hosp, Dept Ophthalmol, Hohenzollernring 74, D-48145 Munster, Germany

[2] Univ Duisburg Essen, Dept Ophthalmol, Essen, Germany

[3] Fachklin Bad Bentheim, Dept Rheumatol, Bad Bentheim, Germany

[4] St Franziskus Hosp Muenster, Dept Internal Med, Munster, Germany

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2023年 / 31卷 / 05期

关键词：

Janus kinase inhibitors; juvenile idiopathic arthritis; therapy; upadacitinib; uveitis;

D O I：

10.1080/09273948.2022.2069128

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objective: Several case reports have been published on the effect of janus kinase inhibitors (JAK-I) on juvenile idiopathic arthritis-associated uveitis (JIAU). Both tofacitinib and baricitinib have been described as therapeutically effective in JIAU. Methods: We here present a case of a 24-years-old female with refractory course of JIAU receiving upadacitinib therapy. Results: After failing multiple conventional and biologic disease-modifying antirheumatic drugs, the patient finally achieved clinical remission on upadacitinib monotherapy, despite a previously unsatisfactory clinical response of both arthritis and uveitis to tofacitinib monotherapy. Conclusion: This case suggests that switching JAK-I might be a successful strategy in the treatment of JIAU, despite previously incomplete response to other preparations.

引用

页码：1079 / 1080

页数：2

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