Cyanidin-3-O-glucoside and its phenolic metabolites ameliorate intestinal diseases via modulating intestinal mucosal immune system: potential mechanisms and therapeutic strategies

被引：30

作者：

Cheng, Zhen ^{[1
,2
]}

Si, Xu ^{[1
,2
]}

Tan, Hui ^{[1
,2
]}

Zang, Zhihuan ^{[1
,2
]}

Tian, Jinlong ^{[1
,2
]}

Shu, Chi ^{[1
,2
]}

Sun, Xiyun ^{[1
,2
]}

Li, Zhiying ^{[1
,2
]}

Jiang, Qiao ^{[1
,2
]}

Meng, Xianjun ^{[1
,2
]}

Chen, Yi ^{[3
]}

Li, Bin ^{[1
,2
]}

Wang, Yuehua ^{[1
,2
]}

机构：

[1] Shenyang Agr Univ, Coll Food Sci, Shenyang, Liaoning, Peoples R China

[2] Shenyang Agr Univ, Natl R&D Profess Ctr Berry Proc, Shenyang, Liaoning, Peoples R China

[3] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Jiangxi, Peoples R China

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2023年 / 63卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Cyanidin-3-O-glucoside; intestinal diseases; intestinal mucosal immune system; phenolic metabolites; gut microbiota; IRRITABLE-BOWEL-SYNDROME; CYANIDIN; 3-O-GLUCOSIDE; GUT MICROBIOTA; CELL-DEATH; ANTIOXIDANT PROPERTIES; PLATELET ACTIVATION; EPITHELIAL-CELLS; HEALTH-BENEFITS; CULTIVARS; TNF-ALPHA;

D O I：

10.1080/10408398.2021.1966381

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The incidence of the intestinal disease is globally increasing, and the intestinal mucosa immune system is an important defense line. A potential environmental cause to regulate gut health is diet. Cyanidin-3-O-glucoside is a natural plant bioactive substance that has shown rising evidence of improving intestinal disease and keeping gut homeostasis. This review summarized the intestinal protective effect of Cyanidin-3-O-glucoside in vivo and in vitro and discussed the potential mechanisms by regulating the intestinal mucosal immune system. Cyanidin-3-O-glucoside and phenolic metabolites inhibited the presence and progression of intestinal diseases and explained from the aspects of repairing the intestinal wall, inhibiting inflammatory reaction, and regulating the gut microbiota. Although the animal and clinical studies are inadequate, based on the accumulated evidence, we propose that the interaction of Cyanidin-3-O-glucoside with the intestinal mucosal immune system is at the core of most mechanisms by which affect host gut diseases. This review puts forward the potential mechanism of action and targeted treatment strategies.

引用

页码：1629 / 1647

页数：19

共 154 条

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