Research progress on the mechanism of common inflammatory pathways in the pathogenesis and development of lymphoma

被引：3

作者：

Shi, Aorong ^{[1
]}

Yun, Fen ^{[1
,2
]}

Shi, Lin ^{[1
,2
]}

Liu, Xia ^{[1
,2
]}

Jia, Yongfeng ^{[1
,2
]}

机构：

[1] Inner Mongolia Med Univ, Basic Med Sci Coll, Dept Pathol, Hohhot, Peoples R China

[2] Inner Mongolia Med Univ, Affiliated Hosp 1, Dept Pathol, Hohhot, Peoples R China

来源：

ANNALS OF MEDICINE | 2024年 / 56卷 / 01期

关键词：

Lymphomas; inflammatory pathways; tumour microenvironment; immune regulation; NF-KAPPA-B; CELL-CYCLE ARREST; HODGKIN LYMPHOMA; TRANSCRIPTION FACTOR; PTEN LOSS; MUTATIONS; KINASE; ACTIVATION; AKT; PROTEIN;

D O I：

10.1080/07853890.2024.2329130

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years, the incidence and mortality rates of lymphoma have gradually increased worldwide. Tumorigenesis and drug resistance are closely related to intracellular inflammatory pathways in lymphoma. Therefore, understanding the biological role of inflammatory pathways and their abnormal activation in relation to the development of lymphoma and their selective modulation may open new avenues for targeted therapy of lymphoma. The biological functions of inflammatory pathways are extensive, and they are central hubs for regulating inflammatory responses, immune responses, and the tumour immune microenvironment. However, limited studies have investigated the role of inflammatory pathways in lymphoma development. This review summarizes the relationship between abnormal activation of common inflammatory pathways and lymphoma development to identify precise and efficient targeted therapeutic options for patients with advanced, drug-resistant lymphoma. Inflammatory pathways directly or indirectly regulate the TME and are closely related to the development of lymphoma.This review was conducted to elucidate the connection between inflammatory pathways and the tumorigenesis and drug resistance of several common lymphomas.Overall, targeting abnormally activated molecules upstream and downstream of lymphoma inflammatory pathways in the future is expected to be a new target for lymphoma treatment.

引用

页数：13

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