Myosteatosis predicts short-term mortality in patients with COVID-19 A multicenter analysis

被引:2
作者
Surov, Alexey [1 ]
Meyer, Hans Jonas [2 ]
Ehrengut, Constantin [2 ]
Zimmermann, Silke [3 ]
Schramm, Dominik [4 ]
Hinnerichs, Mattes [5 ]
Baer, Caroline [5 ]
Borggrefe, Jan [1 ]
机构
[1] Ruhr Univ Bochum, Johannes Wesling Med Ctr, Dept Radiol Neuroradiol & Nucl Med, Bochum, Germany
[2] Univ Leipzig, Dept Diagnost & Intervent Radiol, Leipzig, Germany
[3] Univ Leipzig, Dept Lab Med, Leipzig, Germany
[4] Univ Halle Wittenberg, Dept Diagnost & Intervent Radiol, Halle, Saale, Germany
[5] Otto von Guericke Univ, Dept Radiol & Nucl Med, Magdeburg, Germany
关键词
Sarcopenia; Myosteatosis; CT; COVID-19; Skeletal muscle; MUSCLE; SURVIVAL; OUTCOMES;
D O I
10.1016/j.nut.2023.112327
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objectives: Body composition on computed tomography can predict prognosis in patients with COVID-19. The reported data are based on small retrospective studies. The aim of the present study was to analyze the prognostic relevance of skeletal muscle parameter derived from chest computed tomography for prediction of 30-d mortality in patients with COVID-19 in a multicenter setting. Methods: The clinical databases of three centers were screened for patients with COVID-19 between 2020 and 2022. Overall, 447 patients (142 female; 31.7%) were included into the study. The mean age at the time of computed tomography acquisition was 63.8 +/- 14.7 y and median age was 65 y. Skeletal muscle area and skeletal muscle density were defined on level T12 of the chest. Results: Overall, 118 patients (26.3%) died within the 30-d observation period. Of the patient sample, 255 patients (57.0%) were admitted to an intensive care unit and 122 patients needed mechanical ventilation (27.3%). The mean skeletal muscle area of all patients was 96.1 +/- 27.2 cm(2) (range = 23.2-200.7 cm(2)). For skeletal muscle density, the mean was 24.3 +/- 11.1 Hounsfield units (range = -5.6 to 55.8 Hounsfield units). In survivors, the mean skeletal muscle density was higher compared with the lethal cases (mean 25.8 +/- 11.2 versus 20.1 +/- 9.6; P < 0.0001). Presence of myosteatosis was independently associated with 30-d mortality: odds ratio = 2.72 (95% CI, 1.71-4.32); P = 0.0001. Conclusions: Myosteatosis is strongly associated with 30-d mortality in patients COVID-19. Patients with COVID-19 with myosteatosis should be considered a risk group. (c) 2023 Elsevier Inc. All rights reserved.
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页数:6
相关论文
共 36 条
  • [1] Chest CT-Derived Muscle Analysis in COVID-19 Patients
    Antonarelli, Maurizio
    Fogante, Marco
    [J]. TOMOGRAPHY, 2022, 8 (01) : 414 - 422
  • [2] The value of computed tomography in assessing the risk of death in COVID-19 patients presenting to the emergency room
    Besutti, Giulia
    Ottone, Marta
    Fasano, Tommaso
    Pattacini, Pierpaolo
    Iotti, Valentina
    Spaggiari, Lucia
    Bonacini, Riccardo
    Nitrosi, Andrea
    Bonelli, Efrem
    Canovi, Simone
    Colla, Rossana
    Zerbini, Alessandro
    Massari, Marco
    Lattuada, Ivana
    Ferrari, Anna Maria
    Rossi, Paolo Giorgi
    [J]. EUROPEAN RADIOLOGY, 2021, 31 (12) : 9164 - 9175
  • [3] Visual lung damage CT score at hospital admission of COVID-19 patients and 30-day mortality
    Charpentier, Etienne
    Soulat, Gilles
    Fayol, Antoine
    Hernigou, Anne
    Livrozet, Marine
    Grand, Teodor
    Reverdito, Guillaume
    al Haddad, Jad
    Dang Tran, Kim Diep
    Charpentier, Anne
    Clement, Olivier
    Hulot, Jean-Sebastien
    Mousseaux, Elie
    [J]. EUROPEAN RADIOLOGY, 2021, 31 (11) : 8354 - 8363
  • [4] Sarcopenia: imaging assessment and clinical application
    Chianca, Vito
    Albano, Domenico
    Messina, Carmelo
    Gitto, Salvatore
    Ruffo, Gaetano
    Guarino, Salvatore
    Del Grande, Filippo
    Sconfienza, Luca Maria
    [J]. ABDOMINAL RADIOLOGY, 2022, 47 (09) : 3205 - 3216
  • [5] Variation in COVID-19 characteristics, treatment and outcomes in Michigan: an observational study in 32 hospitals
    Chopra, Vineet
    Flanders, Scott A.
    Vaughn, Valerie
    Petty, Lindsay
    Gandhi, Tejal
    McSparron, Jakob Israel
    Malani, Anurag
    O'Malley, Megan
    Kim, Tae
    McLaughlin, Elizabeth
    Prescott, Hallie
    [J]. BMJ OPEN, 2021, 11 (07):
  • [6] Optimal body size adjustment of L3 CT skeletal muscle area for sarcopenia assessment
    Derstine, Brian A.
    Holcombe, Sven A.
    Ross, Brian E.
    Wang, Nicholas C.
    Su, Grace L.
    Wang, Stewart C.
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [7] Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients
    Dessie, Zelalem G.
    Zewotir, Temesgen
    [J]. BMC INFECTIOUS DISEASES, 2021, 21 (01)
  • [8] Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
    Fernandes, Queenie
    Inchakalody, Varghese Philipose
    Merhi, Maysaloun
    Mestiri, Sarra
    Taib, Nassiba
    El-Ella, Dina Moustafa Abo
    Bedhiafi, Takwa
    Raza, Afsheen
    Al-Zaidan, Lobna
    Mohsen, Mona O.
    Al-Nesf, Mariam Ali Yousuf
    Hssain, Ali Ait
    Yassine, Hadi Mohamad
    Bachmann, Martin F.
    Uddin, Shahab
    Dermime, Said
    [J]. ANNALS OF MEDICINE, 2022, 54 (01) : 524 - 540
  • [9] Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30211-7, 10.1016/S0140-6736(20)30183-5]
  • [10] Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19
    Kang, Min-Kyu
    Lee, Yu-Rim
    Song, Jeung-Eun
    Kweon, Young-Oh
    Tak, Won-Young
    Jang, Se-Young
    Park, Jung-Gil
    Park, Soo-Young
    [J]. DIAGNOSTICS, 2022, 12 (09)