Epidemiology of Vancomycin in Combination With Piperacillin/Tazobactam-Associated Acute Kidney Injury in Children: A Systematic Review and Meta-analysis

被引:1
作者
Zhang, Miao [1 ,2 ,3 ,4 ,5 ]
Huang, Liang [1 ,2 ,3 ,4 ]
Zhu, Yu [4 ,6 ]
Zeng, Linan [1 ,2 ,3 ,4 ]
Jia, Zhi-Jun [1 ,2 ,3 ,4 ,5 ]
Cheng, Guo [4 ,6 ,7 ]
Li, Hailong [1 ,2 ,3 ,4 ,9 ]
Zhang, Lingli [1 ,2 ,3 ,4 ,8 ,9 ]
机构
[1] Sichuan Univ, West China Second Univ Hosp, Dept Pharm, Chengdu, Peoples R China
[2] Sichuan Univ, West China Second Univ Hosp, Evidence Based Pharm Ctr, Chengdu, Peoples R China
[3] NMPA Key Lab Tech Res Drug Prod Vitro & Vivo Corre, Chengdu, Peoples R China
[4] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China
[5] Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China
[6] Sichuan Univ, West China Second Univ Hosp, Dept Pediat, Chengdu, Peoples R China
[7] Sichuan Univ, Ctr Translat Med, Lab Mol Translat Med, Chengdu, Peoples R China
[8] Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Sichuan, Peoples R China
[9] Sichuan Univ, West China Second Univ Hosp, Dept Pharm, Chengdu 610041, Peoples R China
关键词
acute kidney injury; vancomycin; piperacillin/tazobactam; incidence; risk factor; CRITICALLY-ILL CHILDREN; CONCOMITANT VANCOMYCIN; INDUCED NEPHROTOXICITY; HOSPITALIZED CHILDREN; TAZOBACTAM; OUTCOMES; THERAPY; INFANTS; QUALITY; PRIFLE;
D O I
10.1177/10600280231220379
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Several studies have shown that vancomycin combined with piperacillin/tazobactam (VPT) increased the risk of acute kidney injury (AKI) compared with other antibiotics in children. However, the epidemiology of VPT-associated AKI in children is unknown. Objective: To evaluate the incidence and risk factors of VPT-associated AKI in children. Data sources: Literature databases of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Database, WanFang Database, and China Biology Medicine Disc were searched from inception to November 2023. References of included studies were also manually checked. Study selection and data extraction: Two independent reviewers selected studies, extracted data, and quality assessment. Meta-analyses were performed to quantify the incidence and risk factors of VPT-associated AKI in children. Data synthesis: Sixteen cohort studies were identified. Overall, the incidence of VPT-associated AKI in children was 24.3% (95% CI: 17.9%-30.6%). The incidence of VPT-associated AKI in critically ill children (26.6%) was higher than that in noncritically ill children (10.9%). Moreover, higher serum vancomycin trough concentration (>15 mg/L), use of vasopressors, combination of nephrotoxins and intensive care unit admission were risk factors for VPT-associated AKI in children (P < 0.05). Relevance to patient care and clinical practice: Identifying high-risk groups and determining safer treatments is critical to reducing the incidence of VPT-associated AKI in children. Conclusions: The incidence of VPT-associated AKI in children is high, especially in critically ill children. Medication regimens should be personalized based on the presence of individual risk factors. Moreover, renal function was regularly assessed throughout treatment with VPT.
引用
收藏
页码:1034 / 1044
页数:11
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