Varying material thickness of silicone rubber for tunable nitric oxide release

被引：1
作者：
Maffe, Patrick [1 ]
Devine, Ryan [1 ]
Garren, Mark [1 ]
Handa, Hitesh [1 ,2 ,3 ]
机构：
[1] Univ Georgia, Coll Engn, Sch Chem Mat & Biomed Engn, Athens, GA USA
[2] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA USA
[3] Univ Georgia, Coll Engn, iSTEM 2, 302 East Campus Rd, Athens, GA 30602 USA
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2024年 / 112卷 / 02期
基金：
美国国家卫生研究院;
关键词：
nitric oxide; polydimethylsiloxane; polymer thickness; silicone rubber; S-nitrosothiol-N-acetylpenicillamine; solvent swelling; N-ACETYLPENICILLAMINE SNAP; IMPROVED HEMOCOMPATIBILITY; STABILITY; STERILIZATION; POLYMER; MODEL;
D O I：
10.1002/jbm.b.35377
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Silicone rubber (SR), a common medical-grade polymer used in medical devices, has previously been modified for nitric oxide (NO) releasing capabilities. However, the effects of material properties such as film thickness on NO release kinetics are not well explored. In this study, SR is used in the first analysis of how a polymer's thickness affects the storage and uptake of an NO donor and subsequent release properties. Observed NO release trends show that a polymer's thickness results in tunable NO release. These results indicate how crucial a polymer's thickness is to optimize the NO release in an efficient and effective method. image
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页数：8
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