Effects of Indonesian Shortfin Eel (Anguilla bicolor) By-Product Oil Supplementation on HOMA-IR and Lipid Profile in Obese Male Wistar Rats

被引：0

作者：

Megawati, Ginna ^{[1
,2
]}

Syahruddin, Siti Shofiah ^{[3
]}

Tjandra, Winona ^{[3
]}

Kusumawati, Maya ^{[4
]}

Herawati, Dewi Marhaeni Diah ^{[2
]}

Gurnida, Dida Achmad ^{[5
]}

Musfiroh, Ida ^{[6
]}

机构：

[1] Univ Padjadjaran, Fac Med, Doctoral Study Program, Bandung 40161, Indonesia

[2] Univ Padjadjaran, Fac Med, Dept Publ Hlth, Div Med Nutr, Sumedang 45363, Indonesia

[3] Univ Padjadjaran, Fac Med, Med Undergrad Program, Sumedang 45363, Indonesia

[4] Univ Padjadjaran, Hasan Sadikin Hosp, Fac Med, Dept Internal Med, Bandung 40161, Indonesia

[5] Univ Padjadjaran, Hasan Sadikin Hosp, Fac Med, Dept Child Hlth, Bandung 40161, Indonesia

[6] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut Anal & Med Chem, Sumedang 45363, Indonesia

来源：

NUTRIENTS | 2023年 / 15卷 / 18期

关键词：

Indonesian shortfin eel by-product oil; fish oil supplementation; n-3 fatty acids; omega-3; HOMA-IR; lipid profiles; total cholesterol; LDL; HDL; triglyceride; POLYUNSATURATED FATTY-ACIDS; ADIPOSE-TISSUE FUNCTION; DIET-INDUCED OBESITY; HIGH-FISH-OIL; EICOSAPENTAENOIC ACID; INSULIN-RESISTANCE; METABOLIC DISTURBANCES; CARDIOVASCULAR-DISEASE; MESSENGER-RNA; MICE;

D O I：

10.3390/nu15183904

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The prevalence of people being overweight and obese has increased globally over the past decades. The use of omega-3 fatty acids-a compound usually primarily found in fish oil-has been known to improve the metabolic profile of obese patients. As the demand for eels increases, the number of waste products from the eels increases and creates environmental problems. This study was conducted to investigate the effect of a newly discovered Indonesian Shortfin eel by-product oil supplementation on the Homeostasis Model Assessment-Estimated Insulin Resistance (HOMA-IR) and lipid profiles of obese male (Lee index >= 0.3) Wistar rats (Rattus norvegicus). The oil was extracted from waste products (heads). Fifteen obese rats were divided into three groups and were administered NaCl (C), commercial fish oil (CO), and Indonesian shortfin eel by-product oil (EO). All groups had statistically significant differences in total cholesterol, LDL, and triglyceride levels (p < 0.05). The CO and EO group showed a significant decrease in total cholesterol, LDL, and triglyceride after treatment. However, no significant difference was found in HDL levels and HOMA-IR. The supplementation of Indonesian shortfin eel by-product oil significantly improved lipid profile while effectively mitigating environmental challenges.

引用

页数：15