Early heart rate variability changes during acute fetal inflammatory response syndrome: An experimental study in a fetal sheep model

被引:2
作者
Chevalier, Geoffroy [1 ,2 ]
Garabedian, Charles [1 ,2 ]
Pekar, Jean David [3 ]
Wojtanowski, Anne [4 ]
Le Hesran, Delphine [2 ]
Galan, Louis Edouard [2 ]
Sharma, Dyuti [1 ,5 ]
Storme, Laurent [1 ,6 ]
Houfflin-Debarge, Veronique [1 ,2 ]
De Jonckheere, Julien [1 ,4 ]
Ghesquiere, Louise [1 ,2 ]
机构
[1] Univ Lille, CHU Lille, Evaluat Technol Sante & Prat Med, ULR 2694,METRICS, Lille, France
[2] CHU Lille, Dept Obstet, Lille, France
[3] CHU Lille, Automated Biochem UF 8832, Lille, France
[4] CHU Lille, CIC IT 1403, Lille, France
[5] CHU Lille, Dept Pediat Surg, Lille, France
[6] CHU Lille, Dept Neonatol, Lille, France
来源
PLOS ONE | 2023年 / 18卷 / 11期
关键词
PRETERM; SEPSIS; POWER;
D O I
10.1371/journal.pone.0293926
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Introduction Fetal infection during labor with fetal inflammatory response syndrome (FIRS) is associated with neurodevelopmental disabilities, cerebral palsy, neonatal sepsis, and mortality. Current methods to diagnose FIRS are inadequate. Thus, the study aim was to explore whether fetal heart rate variability (HRV) analysis can be used to detect FIRS. Material and methods In chronically instrumented near-term fetal sheep, lipopolysaccharide (LPS) was injected intravenously to model FIRS. A control group received saline solution injection. Hemodynamic, blood gas analysis, interleukin-6 (IL-6), and 14 HRV indices were recorded for 6 h. In both groups, comparisons were made between the stability phase and the 6 h following injection (H1-H6, respectively) and between LPS and control groups. Results Fifteen lambs were instrumented. In the LPS group (n = 8), IL-6 increased significantly after LPS injection (p < 0.001), confirming the FIRS model. Fetal heart rate increased significantly after H5 (p < 0.01). In our FIRS model without shock or cardiovascular decompensation, five HRV measures changed significantly after H2 until H4 in comparison to baseline. Moreover, significant differences between LPS and control groups were observed in HRV measures between H2 and H4. These changes appear to be mediated by an increase of global variability and a loss of signal complexity. Conclusion As significant HRV changes were detected before FHR increase, these indices may be valuable for early detection of acute FIRS.
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页数:15
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