Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo

被引：5

作者：

Blengio, Fabiola ^{[1
]}

Hocini, Hakim ^{[1
]}

Richert, Laura ^{[1
,2
,3
]}

Lefebvre, Cecile ^{[1
]}

Durand, Melany ^{[2
,3
]}

Hejblum, Boris ^{[1
,2
,3
]}

Tisserand, Pascaline ^{[1
]}

McLean, Chelsea ^{[4
]}

Luhn, Kerstin ^{[4
]}

Thiebaut, Rodolphe ^{[1
,2
,3
]}

Levy, Yves ^{[1
,5
]}

机构：

[1] Univ Paris Est Creteil, Vaccine Res Inst, Fac Med, Team 16,INSERM U955, Creteil, France

[2] Univ Bordeaux, INSERM Bordeaux Populat Hlth Res Ctr, Dept Publ Hlth, Inria SISTM,UMR 1219, Bordeaux, France

[3] CHU Bordeaux, Serv Informat Med, Pole Sante Publ, Bordeaux, France

[4] Janssen Vaccines & Prevent BV, Leiden, Netherlands

[5] Grp Henri Mondor Albert Chenevier, AP HP, Serv Immunol Clin, Creteil, France

来源：

CELL REPORTS | 2023年 / 42卷 / 09期

关键词：

SYSTEMS BIOLOGY; REGULARIZATION PATHS; CELL RESPONSES; B-CELLS; T-CELL; ACTIVATION; IMMUNOGENICITY; PATHOGENESIS; INFLUENZA; PACKAGE;

D O I：

10.1016/j.celrep.2023.113101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome pro-files at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an increase in genes related to antigen presentation, sensing, and T and B cell recep-tors. The highest response occurs 1 day after Ad26.ZEBOV injection, with an increase of the gene expression of interferon-induced antiviral molecules, monocyte activation, and sensing receptors. This response is regu-lated by the HESX1, ATF3, ANKRD22, and ETV7 transcription factors. A plasma cell signature is observed on day 7 post-Ad26.ZEBOV vaccination, with an increase of CD138, MZB1, CD38, CD79A, and immunoglobulin genes. We have identified early expressed genes correlated with the magnitude of the antibody response 21 days after the MVA-BN-Filo and 364 days after Ad26.ZEBOV vaccinations. Our results provide early gene signatures that correlate with vaccine-induced Ebola virus glycoprotein-specific antibodies.

引用

页数：19

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