Mechanisms of Cardiac Repair in Cell Therapy

被引：2

作者：

Collet, Berenice C. ^{[1
,2
]}

Davis, Darryl R. ^{[1
,2
,3
]}

机构：

[1] Univ Ottawa, Heart Inst, Dept Med, Div Cardiol, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

[3] Univ Ottawa, Heart Inst, H3214,40 Ruskin St, Ottawa, ON K1Y 4W7, Canada

来源：

HEART LUNG AND CIRCULATION | 2023年 / 32卷 / 07期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

Heart failure; Cell therapy; Regeneration; Myocardial infarction; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL PROGENITOR CELLS; CARDIOSPHERE-DERIVED CELLS; LEFT-VENTRICULAR FUNCTION; MARROW MONONUCLEAR-CELLS; HEMATOPOIETIC STEM-CELLS; CHRONIC HEART-FAILURE; INTRACORONARY INJECTION; ISCHEMIC CARDIOMYOPATHY; TRANSPLANTATION;

D O I：

10.1016/j.hlc.2023.01.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring damaged hearts to working condition. But progress has not been straightforward as many of our initial assumptions turned out to be wrong. In this review, we critically examine the last 20 years of progress in cardiac cell therapy and focus on several of the popular beliefs surrounding cell therapy to illustrate the mechanisms involved in restoring heart function after cardiac injury. Are they true or false?

引用

页码：825 / 835

页数：11

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