The therapeutic potential of natural killer cells in neuropathic pain

被引：9

作者：

Kim, Hyoung Woo ^{[1
,2
]}

Wang, Shuaiwei ^{[3
]}

Davies, Alexander J. ^{[3
]}

Oh, Seog Bae ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Sch Dent, Dept Neurobiol & Physiol, Seoul, South Korea

[2] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea

[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

来源：

TRENDS IN NEUROSCIENCES | 2023年 / 46卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

CD8(+) T-CELLS; NK-CELLS; IFN-GAMMA; TNF-ALPHA; CYTOKINE PRODUCTION; LYMPHOID-CELLS; RECEPTOR; NEURONS; INJURY; NKG2D;

D O I：

10.1016/j.tins.2023.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Novel disease-modifying treatments for neuropathic pain are urgently required. The cellular immune response to nerve injury represents a promising target for therapeutic development. Recently, the role of natural killer (NK) cells in both CNS and PNS disease has been the subject of growing interest. In this opinion article, we set out the case for NK cell-based intervention as a promising avenue for development in the management of neuropathic pain. We explore the poten-tial cellular and molecular targets of NK cells in the PNS by contrasting with their reported functional roles in CNS diseases, and we suggest strategies for using the beneficial functions of NK cells and immune-based therapeutics in the con-text of neuropathic pain.

引用

页码：617 / 627

页数：11

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