Uncoupling elephant TP53 and cancer

被引：2
作者：
Vollrath, Fritz [1 ]
机构：
[1] Univ Oxford, Dept Biol, Oxford OX1 3PS, England
来源：
TRENDS IN ECOLOGY & EVOLUTION | 2023年 / 38卷 / 08期
关键词：
P53;
D O I：
10.1016/j.tree.2023.05.011
中图分类号：
Q14 [生态学（生物生态学）];
学科分类号：
071012 ; 0713 ;
摘要：
Elephant testicles do not descend, with implications for sperm production being hot enough to compromise germline DNA replication/ repair. Uniquely, elephants also possess 20 copies of a gene encoding for the p53 protein. Did elephants evolve multiplication of the TP53 gene complex to protect their germline rather than to fight cancer?
引用
收藏
页码：705 / 707
页数：3
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