Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer

被引：2
作者：
Badesha, Jasleen K. [1 ]
Zhou, Marilyn [1 ]
Arif, Arif A. [1 ,2 ]
Gill, Sharlene [1 ,2 ]
Speers, Caroline [1 ]
Peacock, Michael [1 ,2 ]
De Vera, Mary A. [2 ]
Stuart, Heather C. [2 ]
Brown, Carl J. [2 ,4 ]
Donellan, Fergal [2 ,3 ]
Loree, Jonathan M. [1 ,2 ,5 ]
机构：
[1] BC Canc, Vancouver, BC, Canada
[2] Univ British Columbia, Vancouver, BC, Canada
[3] Vancouver Gen Hosp, Vancouver, BC, Canada
[4] St Pauls Hosp, Vancouver, BC, Canada
[5] BC Canc, Div Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
来源：
CANCER RESEARCH COMMUNICATIONS | 2023年 / 3卷 / 04期
关键词：
TOTAL MESORECTAL EXCISION; COLORECTAL-CANCER; POSTOPERATIVE CHEMORADIOTHERAPY; SPHINCTER PRESERVATION; FOLLOW-UP; CHEMORADIATION; MULTICENTER; SURVIVAL; TRIAL; YOUNG;
D O I：
10.1158/2767-9764.CRC-22-0385
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Preoperative radiotherapy for early-stage rectal cancer has risks and benefits that may impact treatment choice in young patients. We reviewed radiotherapy use and outcomes for rectal cancer by age. Patients with early-stage rectal cancer in the Canadian province of British Columbia from 2002 to 2016 were identified (n = 6,232). Baseline characteristics, disease-specific survival (DSS), and locoregional recurrence rate (LRR) were compared between patients <50 (early-onset; n = 532) and & GE;50 years old (average-onset; n = 5,700). Early-onset patients were more likely to receive preoperative chemoradiotherapy than short-course radiotherapy [OR, 2.20; 95% confidence interval (CI), 1.67-2.89; P < 0.0001], but also had higher nodal (P = 0.00096) and overall clinical staging (P = 0.033). Cancer downstaging and pathologic complete response rates were similar
引用
收藏
页码：548 / 557
页数：10
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