Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications

被引：6

作者：

Zheng, Qi ^{[1
]}

Wang, Weitao ^{[2
]}

Zhou, Yuhang ^{[1
]}

Mo, Jiayin ^{[1
]}

Chang, Xinyue ^{[1
]}

Zha, Zhengbao ^{[2
]}

Zha, Lisha ^{[1
]}

机构：

[1] Anhui Agr Univ, Int Immunol Ctr, Hefei 230036, Peoples R China

[2] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2023年 / 11卷 / 16期

基金：

中国国家自然科学基金;

关键词：

BLACK PHOSPHORUS NANOSHEETS; ADAPTIVE IMMUNE-SYSTEMS; CRISPR-CAS9; SYSTEM; DRUG-DELIVERY; MEDIATED DELIVERY; GRAPHENE OXIDE; CAS9; RIBONUCLEOPROTEIN; GOLD NANOPARTICLES; EFFICIENT DELIVERY; NONVIRAL DELIVERY;

D O I：

10.1039/d3bm00788j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Gene editing has great potential in biomedical research including disease diagnosis and treatment. Clustered regularly interspaced short palindromic repeats (CRISPR) is the most straightforward and cost-effective method. The efficient and precise delivery of CRISPR can impact the specificity and efficacy of gene editing. In recent years, synthetic nanoparticles have been discovered as effective CRISPR/Cas9 delivery vehicles. We categorized synthetic nanoparticles for CRISPR/Cas9 delivery and discribed their advantages and disadvantages. Further, the building blocks of different kinds of nanoparticles and their applications in cells/tissues, cancer and other diseases were described in detail. Finally, the challenges encountered in the clinical application of CRISPR/Cas9 delivery materials were discussed, and potential solutions were provided regarding efficiency and biosafety issues.

引用

页码：5361 / 5389

页数：30

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