Evolving Landscape of Targeted Treatment Options for HER2-Positive Gastric/Gastroesophageal Adenocarcinomas

被引：0

作者：

Epistola, Raisa ^{[1
,3
]}

Chao, Joseph ^{[2
]}

Lee, Jennifer ^{[1
]}

机构：

[1] Harbor UCLA Med Ctr, Div Hematol & Med Oncol, Torrance, CA USA

[2] City Hope Comprehens Canc Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA USA

[3] 1000 West Carson St,N18, Torrance, CA 90502 USA

来源：

CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY | 2023年 / 21卷 / 06期

关键词：

Gastric cancer  gastroesophageal adenocarcinoma; gastroesophageal cancer; HER2; GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA; TRASTUZUMAB EMTANSINE; GASTRIC-CANCER; LAPATINIB; THERAPY; CHEMOTHERAPY; OXALIPLATIN; COMBINATION; PACLITAXEL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric and gastroesophageal adenocarcinomas are aggressive malignancies despite current standard-of-care treat-ments. For patients whose tumors express human epidermal growth factor receptor 2 (HER2), HER2-targeted treatments have been shown to improve outcomes. This review summarizes key trials that have guided contemporary use of these agents in both the localized and advanced settings. It also discusses limitations to current approaches in testing HER2 status and methods to better identify good candidates for these treatments. Finally, the review highlights notable ongoing studies investigating novel combina-tions and HER2-directed agents.

引用

页码：312 / 320

页数：9

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