Target-based screening for natural products against Staphylococcus aureus biofilms

被引:38
作者
Guo, Na [1 ]
Bai, Xue [1 ]
Shen, Yong [1 ]
Zhang, Tiehua [1 ]
机构
[1] Jilin Univ, Coll Food Sci & Engn, Changchun, Peoples R China
关键词
anti-biofilm agent; food; natural products; Staphylococcus aureus; target-oriented screening; ANTIMICROBIAL ACTIVITY; MOLECULAR-MECHANISMS; ESCHERICHIA-COLI; ESSENTIAL OILS; EXPRESSION; STRAINS; ACID; ANTIBIOFILM; INHIBITION; PHENOTYPE;
D O I
10.1080/10408398.2021.1972280
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
As a notorious food-borne pathogen, Staphylococcus aureus can readily cause diseases in humans via contaminated food. Biofilm formation on various surfaces can increase the capacity of viable S. aureus cells for self-protection due to the stubborn structure of the biofilm matrix. Increased disease risk and economic losses caused by biofilm contamination in the food industry necessitate the urgent development of effective strategies for the inhibition and removal of S. aureus biofilms. Natural products have been extensively used as important sources of "eco-friendly" antibiofilm agents to avoid the side effects of conventional strategies on human health and the environment. This review discusses biofilm formation of S. aureus in food industries and focuses on providing an overview of potential promising target-oriented natural products and their mechanisms of S. aureus biofilm inhibition or removal. Hoping to provide valuable information of attractive research targets or potential undeveloped targets to screen potent natural anti-biofilm agents in food industries.
引用
收藏
页码:2216 / 2230
页数:15
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