Role of Liraglutide Use in Patients With Heart Failure

被引：0

作者：

Allam, Sanjana ^{[1
]}

Sartaj, Sahil ^{[2
]}

Moquim, Hiba ^{[3
]}

Husnain, Muhammad Ammar ^{[4
,5
]}

Bustos, Daniel ^{[6
]}

Lakkimsetti, Mohit ^{[7
]}

Randhawa, Avneet K. ^{[8
]}

Gupta, Ishita ^{[9
]}

机构：

[1] Gandhi Med Coll, Internal Med, Secunderabad, India

[2] Melmaruvathur Adiparasakthi Inst Med Sci & Res, Internal Med, Melmaruvathur, India

[3] Shadan Inst Med Sci, Internal Med, Hyderabad, Pakistan

[4] Combined Mil Hosp, Lahore Med Coll, Internal Med, Lahore, Pakistan

[5] Inst Dent, Lahore, Pakistan

[6] Pontif Catholic Univ Ecuador, Internal Med, Quito, Ecuador

[7] Mamata Med Coll, Internal Med, Khammam, India

[8] Maharishi Markandeshwar Inst Med Sci & Res, Internal Med, Ambala, India

[9] Dr Rajendra Prasad Govt Med Coll, Internal Med, Kangra, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 12期

关键词：

glucagon-like peptide-1 receptor agonist (glp-1 ra); review of clinical trials; management of heart failure; glp-1; analogs; literature review; pub-med indexed research; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction; liraglutide; PEPTIDE-1 RECEPTOR AGONISTS; REDUCED EJECTION FRACTION; BASE-LINE CHARACTERISTICS; CARDIOVASCULAR OUTCOMES; KIDNEY OUTCOMES; GLP-1; EPIDEMIOLOGY; SEMAGLUTIDE; DISEASE; WEIGHT;

D O I：

10.7759/cureus.50065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a clinical condition in which the heart is unable to maintain adequate cardiac output. Liraglutide is a glucagon-like peptide 1 (GLP-1) analogue that is used for the treatment of type 2 diabetes mellitus, but recent evidence suggests that it might have a beneficial role in treating heart failure. We conducted a review of existing literature and found five relevant studies. Data from these studies were extracted and then extrapolated into results following analysis. Four of the five studies found an increase in heart rate in heart failure patients. All five studies reported an increased rate of hospitalization. The five studies also showed an increased risk of adverse effects such as arrhythmia, ventricular tachycardia, atrial fibrillation, and worsening of heart failure. Given the scarcity of evidence in the available literature on liraglutide in heart failure, more research on this population is required.

引用

页数：11

共 45 条

[1] Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study [J].