Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery

被引：10

作者：

Liu, Yun ^{[1
,2
]}

Wang, Yanfang ^{[1
,2
]}

Yao, Yuejun ^{[1
,2
]}

Zhang, Juan ^{[1
,2
]}

Liu, Wei ^{[1
,2
]}

Ji, Kangfan ^{[1
,2
]}

Wei, Xinwei ^{[1
,2
]}

Wang, Yuanwu ^{[1
]}

Liu, Xiangsheng ^{[3
]}

Zhang, Shiming ^{[4
]}

Wang, Jinqiang ^{[1
,2
,5
]}

Gu, Zhen ^{[1
,2
,6
,7
,8
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Key Lab Adv Drug Delivery Syst Zhejiang Prov, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Peoples R China

[3] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China

[4] Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong 999077, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China

[6] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310009, Peoples R China

[7] Zhejiang Univ, Zhejiang Lab Syst & Precis Med, Med Ctr, Hangzhou 310009, Peoples R China

[8] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310009, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 20期

基金：

国家重点研发计划;

关键词：

Diabetes; Drug Delivery; Glucose-Responsive; Insulin Delivery; Lipid Nanoparticles; CATIONIC COPOLYMER HYDROGELS; LIPOSOMES; CELLS; DESIGN; SIRNA;

D O I：

10.1002/anie.202303097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipid nanoparticle-based drug delivery systems have a profound clinical impact on nucleic acid-based therapy and vaccination. Recombinant human insulin, a negatively-charged biomolecule like mRNA, may also be delivered by rationally-designed positively-charged lipid nanoparticles with glucose-sensing elements and be released in a glucose-responsive manner. Herein, we have designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles in an aqueous solution. Upon mixing insulin and the lipid nanoparticles, a heterostructured insulin complex is formed immediately arising from the electrostatic attraction. In a hyperglycemia-relevant glucose solution, lipid nanoparticles become less positively charged over time, leading to reduced attraction and subsequent insulin release. Compared with native insulin, this lipid nanoparticle-based glucose-responsive insulin shows prolonged blood glucose regulation ability and blood glucose-triggered insulin release in a type 1 diabetic mouse model.

引用

页数：6

共 40 条

[21] Emerging micro-and nanotechnology based synthetic approaches for insulin delivery [J].

Mo, Ran ;

Jiang, Tianyue ;

Di, Jin ;

Tai, Wanyi ;

Gu, Zhen .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (10) :3595-3629

[22]

Obika S, 1999, BIOL PHARM BULL, V22, P187

[23] Physicochemical, foundations and structural design of hydrogels in medicine and biology [J].

Peppas, NA ;

Huang, Y ;

Torres-Lugo, M ;

Ward, JH ;

Zhang, J .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2000, 2 :9-29

[24] Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts [J].

Podual, K ;

Doyle, FJ ;

Peppas, NA .

JOURNAL OF CONTROLLED RELEASE, 2000, 67 (01) :9-17

[25] Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase [J].

Podual, K ;

Doyle, FJ ;

Peppas, NA .

POLYMER, 2000, 41 (11) :3975-3983

[26] Dynamic behavior of glucose oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH [J].

Podual, K ;

Doyle, FJ ;

Peppas, NA .

BIOMATERIALS, 2000, 21 (14) :1439-1450

[27] A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo [J].

Sato, Yusuke ;

Hatakeyama, Hiroto ;

Sakurai, Yu ;

Hyodo, Mamoru ;

Akita, Hidetaka ;

Harashima, Hideyoshi .

JOURNAL OF CONTROLLED RELEASE, 2012, 163 (03) :267-276

[28] Rational design of cationic lipids for siRNA delivery [J].

Semple, Sean C. ;

Akinc, Akin ;

Chen, Jianxin ;

Sandhu, Ammen P. ;

Mui, Barbara L. ;

Cho, Connie K. ;

Sah, Dinah W. Y. ;

Stebbing, Derrick ;

Crosley, Erin J. ;

Yaworski, Ed ;

Hafez, Ismail M. ;

Dorkin, J. Robert ;

Qin, June ;

Lam, Kieu ;

Rajeev, Kallanthottathil G. ;

Wong, Kim F. ;

Jeffs, Lloyd B. ;

Nechev, Lubomir ;

Eisenhardt, Merete L. ;

Jayaraman, Muthusamy ;

Kazem, Mikameh ;

Maier, Martin A. ;

Srinivasulu, Masuna ;

Weinstein, Michael J. ;

Chen, Qingmin ;

Alvarez, Rene ;

Barros, Scott A. ;

De, Soma ;

Klimuk, Sandra K. ;

Borland, Todd ;

Kosovrasti, Verbena ;

Cantley, William L. ;

Tam, Ying K. ;

Manoharan, Muthiah ;

Ciufolini, Marco A. ;

Tracy, Mark A. ;

de Fougerolles, Antonin ;

MacLachlan, Ian ;

Cullis, Pieter R. ;

Madden, Thomas D. ;

Hope, Michael J. .

NATURE BIOTECHNOLOGY, 2010, 28 (02) :172-U18

[29]

Soto Veliz D., 2023, Smart Med, V2

[30] IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 [J].

Sun, Hong ;

Saeedi, Pouya ;

Karuranga, Suvi ;

Pinkepank, Moritz ;

Ogurtsova, Katherine ;

Duncan, Bruce B. ;

Stein, Caroline ;

Basit, Abdul ;

Chan, Juliana C. N. ;

Mbanya, Jean Claude ;

Pavkov, Meda E. ;

Ramachandaran, Ambady ;

Wild, Sarah H. ;

James, Steven ;

Herman, William H. H. ;

Zhang, Ping ;

Bommer, Christian ;

Kuo, Shihchen ;

Boyko, Edward J. J. ;

Magliano, Dianna J. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2022, 183

← 1 2 3 4 →