Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery

被引：10

作者：

Liu, Yun ^{[1
,2
]}

Wang, Yanfang ^{[1
,2
]}

Yao, Yuejun ^{[1
,2
]}

Zhang, Juan ^{[1
,2
]}

Liu, Wei ^{[1
,2
]}

Ji, Kangfan ^{[1
,2
]}

Wei, Xinwei ^{[1
,2
]}

Wang, Yuanwu ^{[1
]}

Liu, Xiangsheng ^{[3
]}

Zhang, Shiming ^{[4
]}

Wang, Jinqiang ^{[1
,2
,5
]}

Gu, Zhen ^{[1
,2
,6
,7
,8
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Key Lab Adv Drug Delivery Syst Zhejiang Prov, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Peoples R China

[3] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China

[4] Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong 999077, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China

[6] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310009, Peoples R China

[7] Zhejiang Univ, Zhejiang Lab Syst & Precis Med, Med Ctr, Hangzhou 310009, Peoples R China

[8] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310009, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 20期

基金：

国家重点研发计划;

关键词：

Diabetes; Drug Delivery; Glucose-Responsive; Insulin Delivery; Lipid Nanoparticles; CATIONIC COPOLYMER HYDROGELS; LIPOSOMES; CELLS; DESIGN; SIRNA;

D O I：

10.1002/anie.202303097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipid nanoparticle-based drug delivery systems have a profound clinical impact on nucleic acid-based therapy and vaccination. Recombinant human insulin, a negatively-charged biomolecule like mRNA, may also be delivered by rationally-designed positively-charged lipid nanoparticles with glucose-sensing elements and be released in a glucose-responsive manner. Herein, we have designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles in an aqueous solution. Upon mixing insulin and the lipid nanoparticles, a heterostructured insulin complex is formed immediately arising from the electrostatic attraction. In a hyperglycemia-relevant glucose solution, lipid nanoparticles become less positively charged over time, leading to reduced attraction and subsequent insulin release. Compared with native insulin, this lipid nanoparticle-based glucose-responsive insulin shows prolonged blood glucose regulation ability and blood glucose-triggered insulin release in a type 1 diabetic mouse model.

引用

页数：6

共 40 条

[1] A randomized controlled phase II trial of a novel composition of paclitaxel embedded into neutral and cationic lipids targeting tumor endothelial cells in advanced triple-negative breast cancer (TNBC) [J].

Awada, A. ;

Bondarenko, I. N. ;

Bonneterre, J. ;

Nowara, E. ;

Ferrero, J. M. ;

Bakshi, A. V. ;

Wilke, C. ;

Piccart, M. .

ANNALS OF ONCOLOGY, 2014, 25 (04) :824-831

[2] Nanomedicine review: clinical developments in liposomal applications [J].

Beltran-Gracia, Esteban ;

Lopez-Camacho, Adolfo ;

Higuera-Ciapara, Inocencio ;

Velazquez-Fernandez, Jesus B. ;

Vallejo-Cardona, Alba A. .

CANCER NANOTECHNOLOGY, 2019, 10 (01)

[3] Glucose-responsive biopolymer nanoparticles prepared by co-assembly of concanavalin A and amylopectin for insulin delivery [J].

Chang, Ranran ;

Li, Man ;

Ge, Shengju ;

Yang, Jie ;

Sun, Qingjie ;

Xiong, Liu .

INDUSTRIAL CROPS AND PRODUCTS, 2018, 112 :98-104

[4] LONG-TERM SAFETY, EFFICACY AND SIDE-EFFECTS OF CONTINUOUS SUBCUTANEOUS INSULIN INFUSION TREATMENT FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS - A ONE CENTER EXPERIENCE [J].

CHANTELAU, E ;

SPRAUL, M ;

MUHLHAUSER, I ;

GAUSE, R ;

BERGER, M .

DIABETOLOGIA, 1989, 32 (07) :421-426

[5]

Chen ZW, 2018, NAT CHEM BIOL, V14, P86, DOI [10.1038/NCHEMBIO.2511, 10.1038/nchembio.2511]

[6] Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery [J].

Chen, Zhou ;

Zhang, Aili ;

Yang, Zhaogang ;

Wang, Xinmei ;

Chang, Lingqian ;

Chen, Zhaofeng ;

Lee, Ly James .

CURRENT ORGANIC CHEMISTRY, 2016, 20 (17) :1813-1819

[7] Chemistry of Lipid Nanoparticles for RNA Delivery Published as part of the Accounts of Chemical Research special issue "mRNA Therapeutics" [J].

Sahay, Gaurav ;

Eygeris, Yulia ;

Gupta, Mohit ;

Kim, Jeonghwan .

ACCOUNTS OF CHEMICAL RESEARCH, 2022, 55 (01) :2-12

[8] Recent advancements in liposome technology [J].

Filipczak, Nina ;

Pan, Jiayi ;

Yalamarty, Satya Siva Kishan ;

Torchilin, Vladimir P. .

ADVANCED DRUG DELIVERY REVIEWS, 2020, 156 :4-22

[9] Injectable Nano-Network for Glucose-Mediated Insulin Delivery [J].

Gu, Zhen ;

Aimetti, Alex A. ;

Wang, Qun ;

Dang, Tram T. ;

Zhang, Yunlong ;

Veiseh, Omid ;

Cheng, Hao ;

Langer, Robert S. ;

Anderson, Daniel G. .

ACS NANO, 2013, 7 (05) :4194-4201

[10] MECHANISM OF GLUCOSE-INDUCED INSULIN-SECRETION [J].

HEDESKOV, CJ .

PHYSIOLOGICAL REVIEWS, 1980, 60 (02) :442-509

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