3D Printable Hydrogel with Tunable Degradability and Mechanical Properties as a Tissue Scaffold for Pelvic Organ Prolapse Treatment

被引:10
作者
Zhu, Yuxiang [1 ]
Kwok, Tina [2 ]
Haug, Joel C. [2 ,3 ]
Guo, Shenghan [4 ]
Chen, Xiangfan [4 ]
Xu, Weiheng [1 ]
Ravichandran, Dharneedar [1 ]
Tchoukalova, Yourka D. [8 ]
Cornella, Jeffrey L. [6 ]
Yi, Johnny [6 ]
Shefi, Orit [7 ]
Vernon, Brent L. [3 ]
Lott, David G. [5 ,8 ]
Lancaster, Jessica N. [2 ]
Song, Kenan [4 ]
机构
[1] Arizona State Univ, Polytech Sch TPS, Ira A Fulton Sch Engn, 6075 S Innovat Way West, Mesa, AZ 85212 USA
[2] Mayo Clin Arizona, Dept Immunol, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA
[3] Arizona State Univ, Sch Biol & Hlth Syst Engn SBHSE, Dept Biomed Engn, 427 E Tyler Mall, Tempe, AZ 85287 USA
[4] Arizona State Univ, Sch Mfg Syst & Networks MSN, Ira A Fulton Sch Engn, 6075 S Innovat Way West, Mesa, AZ 85212 USA
[5] Mayo Clin Arizona, Dept Otolaryngol, Div Laryngol, Phoenix, AZ USA
[6] Mayo Clin Arizona, Dept Med & Surg Gynecol, 5777 E Mayo Blvd, Phoenix, AZ 85054 USA
[7] Bar Ilan Univ, Inst Nanotechnol, Fac Engn, Gonda Brain Res Ctr, IL-52900 Ramat Gan, Israel
[8] Mayo Clin Arizona, Head & Neck Regenerat Med Lab, Phoenix, AZ USA
关键词
biocompatibility; biodegradability; direct ink writing; image analysis; machine learning; pelvic organ prolapse; PHOTO-CLICK CHEMISTRY; BIOMECHANICAL PROPERTIES; VAGINAL TISSUE; URINARY-INCONTINENCE; POLY(VINYL ALCOHOL); CROSS-LINKING; WOMEN; MESH; DEGRADATION; CELLULOSE;
D O I
10.1002/admt.202201421
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Pelvic organ prolapse (POP) is a dysfunction that affects a large proportion of women. Current support scaffolds' lack of biocompatibility, biodegradability, and mechanical compliance are associated with surgical complications including erosion and pain, indicating the urgent need for new tissue scaffolds with customizable functions. A new material that uses polyvinyl alcohol (PVA) as the main ingredient and is chemically tuned to possess suitable mechanical properties and degradation rates for the surgical treatment of POP is developed. Specifically, the thiol-norbornene "click" chemistry enables the sol-gel transition of the biomaterial under UV-light without side-products. Meanwhile, NaOH treatment further toughens the hydrogel with a higher crosslink density. The PVA-based biocompatible ink can be printed with UV-facilitated direct ink writing due to the rapidly UV-initiated chemical crosslink; in situ image analysis and machine learning methods are applied during this procedure to quantify and improve the printing quality. The cell viability results demonstrate the biocompatibility of the POP scaffolds, suggesting the potential for future animal studies and the possibility of clinical research. This study bridges polymer chemistry and manufacturing engineering with a specific tissue engineering application to solve the common disorder of POP, shedding light on individualized medicine and intelligent systems for biomedical engineering.
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页数:14
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