Stem cell-derived exosomes for chronic wound repair

被引：7
作者：
Mi, Peng [1 ]
Liu, Jia-Lin [1 ]
Qi, Bao-Ping [2 ,3 ]
Wei, Ben-Mei [1 ]
Xu, Cheng-Zhi [1 ]
Zhu, Lian [1 ]
机构：
[1] Wuhan Polytech Univ, Sch Chem & Environm Engn, Changqing Garden, Wuhan 430023, Hubei, Peoples R China
[2] Hubei Minzu Univ, Hubei Prov Key Lab Occurrence & Intervent Rheumat, Enshi 445000, Hubei, Peoples R China
[3] Hubei Minzu Univ, Sch Chem & Environm Engn, Xueyuan Rd, Enshi 445000, Hubei, Peoples R China
来源：
CELL AND TISSUE RESEARCH | 2023年 / 391卷 / 03期
关键词：
Stem cells; Exosomes; Chronic wound; Inflammation; Angiogenesis; BFGF;
D O I：
10.1007/s00441-023-03742-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cells possess the capability of self-renewal and multipotency, which endows them with great application potential in wound repair fields. Yet, several problems including immune concerns, ethical debates, and oncogenicity impede the broad and deep advance of stem cell-based products. Recently, owing to their abundant resources, excellent biocompatibility, and ease of being engineered, stem cell-derived exosomes were proved to be promising nanomedicine for curing chronic wounds. What is more, stem cell-derived exosomes are almost the mini record of their maternal cells, which even equipped them with the unique characteristics of stem cells. Chronic wound healing efficacy is dominated by several complicated factors, especially the excessive inflammation conditions and impaired vessels. Therefore, this review tries to concentrate on the current advances of stem cell-derived exosomes for reducing inflammation and promoting angiogenesis in chronic wound healing processes. Last but not least, the existing limitations and future perspectives of stem cell-derived exosomes for chronic wound treatment are also outlined.
引用
收藏
页码：419 / 423
页数：5
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