Osteoinductive calcium phosphate with submicron topography as bone graft substitute for maxillary sinus floor augmentation: A translational study

被引:4
|
作者
van Dijk, Lukas A. A. [1 ,2 ,3 ]
Janssen, Nard G. G. [1 ]
Nurmohamed, Silke J. J. [1 ]
Muradin, Marvick S. M. [1 ]
Longoni, Alessia [1 ,2 ]
Bakker, Robbert C. C. [1 ]
de Groot, Florence G. [3 ]
de Bruijn, Joost D. D. [3 ,4 ]
Gawlitta, Debby [1 ,2 ]
Rosenberg, Antoine J. W. P. [1 ]
机构
[1] Univ Med Ctr Utrecht, Dept Oral & Maxillofacial Surg, Utrecht, Netherlands
[2] Regenerat Med Ctr Utrecht, Utrecht, Netherlands
[3] Kuros Biosci BV, Bilthoven, Netherlands
[4] Queen Mary Univ London, Sch Mat Sci & Engn, London, England
基金
欧盟地平线“2020”;
关键词
bone graft substitutes; clinical study; osteoinductive calcium phosphate; preprosthetic dental surgery; sinus floor augmentation; submicron surface topography; translational research bone regeneration; MESENCHYMAL STEM-CELLS; BETA-TRICALCIUM PHOSPHATE; AUTOGENOUS BONE; BIO-OSS; OSTEOGENIC DIFFERENTIATION; DIFFERENT RATIOS; HEALING TIME; ELEVATION; BIOMATERIALS; MEMBRANE;
D O I
10.1111/clr.14028
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
ObjectivesThe aim of this study was the preclinical and clinical evaluation of osteoinductive calcium phosphate with submicron surface topography as a bone graft substitute for maxillary sinus floor augmentation (MSFA). Material and MethodsA preclinical sheep model of MSFA was used to compare a calcium phosphate with submicron needle-shaped topography (BCPN, MagnetOs Granules, Kuros Biosciences BV) to a calcium phosphate with submicron grain-shaped topography (BCPG) and autologous bone graft (ABG) as controls. Secondly, a 10-patient, prospective, randomized, controlled trial was performed to compare BCPN to ABG in MSFA with two-stage implant placement. ResultsThe pre-clinical study demonstrated that both BCPN and BCPG were highly biocompatible, supported bony ingrowth with direct bone apposition against the material, and exhibited bone formation as early as 3 weeks post-implantation. However, BCPN demonstrated significantly more bone formation than BCPG at the study endpoint of 12 weeks. Only BCPN reached an equivalent amount of bone formation in the available space and a greater proportion of calcified material (bone + graft material) in the maxillary sinus compared to the "gold standard" ABG after 12 weeks. These results were validated in a small prospective clinical study, in which BCPN was found comparable to ABG in implant stability, bone height, new bone formation in trephine core biopsies, and overall clinical outcome. ConclusionThis translational work demonstrates that osteoinductive calcium phosphates are promising bone graft substitutes for MSFA, whereas their bone-forming potential depends on the design of their surface features.Netherlands Trial Register, NL6436.
引用
收藏
页码:177 / 195
页数:19
相关论文
empty
未找到相关数据