Ovarian Cancer Radiosensitivity: What Have We Understood So Far?

被引：6

作者：

Barcellini, Amelia ^{[1
,2
]}

Charalampopoulou, Alexandra ^{[3
]}

De Cecco, Loris ^{[4
]}

Fodor, Andrei ^{[5
]}

Rabaiotti, Emanuela ^{[6
]}

Candotti, Giorgio ^{[6
]}

Secondino, Simona ^{[7
]}

Facoetti, Angelica ^{[3
]}

Locati, Laura Deborah ^{[2
,8
]}

Pignata, Sandro ^{[9
]}

Orlandi, Ester ^{[1
]}

Mangili, Giorgia ^{[6
]}

机构：

[1] Natl Ctr Oncol Hadrontherapy CNAO, Clin Dept, Radiat Oncol Unit, I-27100 Pavia, Italy

[2] Univ Pavia, Dept Internal Med & Med Therapy, I-27100 Pavia, Italy

[3] Natl Ctr Oncol Hadrontherapy CNAO, Res & Dev Dept, Radiobiol Unit, I-27100 Pavia, Italy

[4] Fdn IRCCS Ist Nazl Tumori, Dept Res, Mol Mech Unit, I-20133 Milan, Italy

[5] IRCCS San Raffaele Sci Inst, Dept Radiat Oncol, I-20132 Milan, Italy

[6] IRCCS San Raffaele Sci Inst, Unit Gynaecol & Obstet, I-20132 Milan, Italy

[7] IRCCS Policlin San Matteo, Med Oncol Unit, I-27100 Pavia, Italy

[8] Maugeri Clin Res Inst IRCCS, Translat Oncol Unit, I-27100 Pavia, Italy

[9] IRCCS Fdn G Pascale Napoli, Ist Nazl Tumori, Dept Urol & Gynecol, I-80131 Naples, Italy

来源：

LIFE-BASEL | 2023年 / 13卷 / 01期

关键词：

ovarian cancer; radiobiology; radioresistance; radiosensitivity; radiation; EXHIBITING GENETIC ALTERATIONS; CARCINOMA-CELL-LINES; RADIATION-THERAPY; RADIOTHERAPY; SENSITIVITY; IMMUNOTHERAPY; COMBINATION; EXPRESSION; IMMUNITY; MODEL;

D O I：

10.3390/life13010006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Radiotherapy has been increasingly considered as an active treatment to combine with other approaches (i.e., surgery, chemotherapy, and novel target-based drugs) in ovarian cancers to palliate symptoms and/or to prolong chemotherapy-free intervals. This narrative review aimed to summarize the current knowledge of the radiosensitivity/radioresistance of ovarian cancer which remains the most lethal gynecological cancer worldwide. Indeed, considering the high rate of recurrence in and out of the radiotherapy fields, in the era of patient-tailored oncology, elucidating the mechanisms of radiosensitivity and identifying potential radioresistance biomarkers could be crucial in guiding clinical decision-making.

引用

页数：13

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