Functional Nucleic Acid-Based Immunomodulation for T Cell-Mediated Cancer Therapy

被引：11

作者：

Wu, Hui ^{[1
]}

Lin, Jie ^{[2
]}

Ling, Neng ^{[2
]}

Zhang, Yutong ^{[2
]}

He, Yao ^{[2
]}

Qiu, Liping ^{[1
,2
]}

Tan, Weihong ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou 310022, Zhejiang, Peoples R China

[2] Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Aptamer Engn Ctr Hunan Prov,, Changsha 410082, Hunan, Peoples R China

[3] Shanghai Jiao Tong Univ, Inst Mol Med IMM, Sch Med, Renji Hosp,Coll Chem & Chem Engn, Shanghai 200240, Peoples R China

来源：

ACS NANO | 2023年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

functional nucleic acids; protein regulation; immunomodulation; antigen-presenting cells; T cells; cancer cells; T cell activation; cancer immunotherapy; MESSENGER-RNA VACCINES; MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSES; CIRCULAR RNAS; DNA VACCINES; IMMUNOTHERAPY; APTAMERS; DELIVERY; BINDING; MELANOMA;

D O I：

10.1021/acsnano.3c09861

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

T cell-mediated immunity plays a pivotal role in cancer immunotherapy. The anticancer actions of T cells are coordinated by a sequence of biological processes, including the capture and presentation of antigens by antigen-presenting cells (APCs), the activation of T cells by APCs, and the subsequent killing of cancer cells by activated T cells. However, cancer cells have various means to evade immune responses. Meanwhile, these vulnerabilities provide potential targets for cancer treatments. Functional nucleic acids (FNAs) make up a class of synthetic nucleic acids with specific biological functions. With their diverse functionality, good biocompatibility, and high programmability, FNAs have attracted widespread interest in cancer immunotherapy. This Review focuses on recent research progress in employing FNAs as molecular tools for T cell-mediated cancer immunotherapy, including corresponding challenges and prospects.

引用

页码：119 / 135

页数：17

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