PREPARATION OF CRYSTALLINITY TAILORED SILK FIBROIN-SODIUM ALGINATE BASED FLOATING MICROBEADS FOR NEVIRAPINE DELIVERY

被引：1

作者：

Patil, Bhupesh Digambar ^{[1
]}

Nangare, Sopan Namdev ^{[1
]}

Zawar, Laxmikant Ramvallabh ^{[1
]}

机构：

[1] HR Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, Maharashtra, India

来源：

CELLULOSE CHEMISTRY AND TECHNOLOGY | 2023年 / 57卷 / 5-6期

关键词：

silk fibroin; nevirapine; floating drug delivery; microbeads; crystallinity modulation; solvent annealing; PROLONGED GASTRIC RESIDENCE; DRUG-DELIVERY; SUSTAINED-RELEASE; GEL BEADS; DOSAGE FORM; IN-VITRO; SYSTEM; FORMULATION; MICROSPHERES;

D O I：

10.35812/CelluloseChemTechnol.2023.57.47

中图分类号：

TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];

学科分类号：

0805 ; 080502 ; 0822 ;

摘要：

The present work anticipated crystallinity- tuned silk fibroin (SFIB)-sodium alginate floating microbeads (MB) as a candidate for nevirapine (NEV) sustained release. Briefly, crystallinity tuning was accomplished using solvent annealing. The changes in structural conformation of SFIB were validated using FTIR spectroscopy. Here, the tangent baseline method revealed changes in crystallinity of floating NEV-loaded SFIB-MB. Importantly, solvent annealing offers conversion of amorphous 'alpha-helix' to crystalline 'beta-sheet' of SFIB, helping to modify drug release from the matrix of SFIB-sodium alginate. As well, NEV-loaded SFIB-MB demonstrated good floating profile. The NEV-loaded SFIB-MB with ethanol (ETH-6) annealing for 6 hours shows 25.853% drug release at 12 hours (pH = 1.2), compared to untreated NEV-loaded SFIB-MB (65.132%, 12 hours, log p < 0.0001). The release kinetics of batch ETH-6 revealed first-order release kinetics and Fickian diffusion (n = 0.468) was found to be the drug diffusion mechanism. Therefore, crystallinity-modified floating NEV-loaded SFIB-based MB will open a new door for modified drug delivery.

引用

页码：527 / 539

页数：13

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