Molecular classification of urothelial bladder carcinoma

被引:14
作者
Schwarzova, Lucia [1 ]
Novakova, Zuzana Varchulova [1 ]
Danisovic, Lubos [1 ]
Ziaran, Stanislav [2 ]
机构
[1] Comenius Univ, Inst Med Biol Genet & Clin Genet, Fac Med, Bratislava, Slovakia
[2] Comenius Univ, Fac Med, Dept Urol, Bratislava, Slovakia
关键词
Urothelial bladder carcinoma; Molecular subtypes of bladder tumors; NMIBC; MIBC; Expression; GENE-EXPRESSION; CANCER; TUMOR; SUBTYPES; IDENTIFICATION; BASAL; TAXONOMY; RNA; DIFFERENTIATION; CHEMOTHERAPY;
D O I
10.1007/s11033-023-08689-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Urothelial bladder carcinoma (UC) ranks among the top ten most commonly diagnosed cancers worldwide on an annual basis. The standardized classification system for urothelial bladder tumors is the Tumor, Node, Metastasis classification, which reflects differences between non-muscle-invasive bladder carcinoma (NMIBC) and muscle-invasive bladder carcinoma (MIBC) and it depends on the extent to which tumor has infiltrated the bladder wall and other tissues and organs. NMIBC and MIBC exhibit great intrinsic heterogeneity regarding different prognoses, survival, progression, and treatment outcomes. In recent years, studies based on mRNA expression profiling revealed the existence of biologically relevant molecular subtypes of UC, which show variant molecular features that can provide more precise stratification of UC patients. Here, we present a complex classification of UC based on mRNA expression studies and molecular subtypes of NMIBC and MIBC in detail with regard to different mRNA expression profiles, mutational signatures, and infiltration by non-tumor cells. The possible impact of molecular subtyping on treatment decisions and patients' outcomes is outlined, too.
引用
收藏
页码:7867 / 7877
页数:11
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