Synthesis of 1,4-Benzodiazepines by Palladium-Catalyzed C-N Coupling

被引：2
作者：
Bhardwaj, Pranshu [1 ]
Kaur, Navjeet [1 ,2 ,3 ]
机构：
[1] Banasthali Vidyapith, Dept Chem, Banasthali 304022, Rajasthan, India
[2] Lovely Profess Univ, Dept Chem, Phagwara 144411, Punjab, India
[3] Lovely Profess Univ, Div Res & Dev, Phagwara 144411, Punjab, India
来源：
CURRENT ORGANIC CHEMISTRY | 2023年 / 27卷 / 04期
关键词：
1; 4-Diazepine; 4-benzodiazepine; palladium catalyst; C-N coupling; domino reaction; heterocyclic compounds; MICROWAVE-ASSISTED SYNTHESIS; FORMING REDUCTIVE ELIMINATION; H ACTIVATION; 6-MEMBERED HETEROCYCLES; PRIVILEGED STRUCTURES; FACILE SYNTHESIS; ALPHA-ARYLATION; BOND FORMATION; INTERMOLECULAR AMINOACETOXYLATION; INTRAMOLECULAR DIAMINATION;
D O I：
10.2174/1385272827666230412080929
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,4-benzodiazepines play a valuable role in organic and medicinal chemistry. In this review article, we have mainly discussed the synthesis of various 1,4-benzodiazepines in the presence of a palladium catalyst. Different reactions, such as intramolecular N-arylation, reductive elimination, oxidative addition, intramolecular alkylation, C-H activation, aryl-aryl bond formation, etc., are included. For these types of syntheses, an easy and efficient catalytic domino process has been reported, including the intermolecular or intramolecular reactions. In this review article, we have also discussed catalyst regeneration and some ligand-free Pd-catalyzed reactions.
引用
收藏
页码：282 / 296
页数：15
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