Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies

被引:1
|
作者
Bafleh, Wjdan S. [1 ]
Abdulsamad, Haia M. R. [1 ]
Al-Qaraghuli, Sally M. [1 ]
El Khatib, Riwa Y. [1 ]
Elbahrawi, Rawdah Taha [1 ]
Abdukadir, Azhar Mohamud [1 ]
Alsawae, Shaima M.
Dimassi, Zakia [2 ]
Hamdan, Hamdan [1 ,3 ]
Kashir, Junaid [4 ,5 ]
机构
[1] Khalifa Univ, Coll Med & Hlth Sci, Dept Physiol & Immunol, Abu Dhabi, U Arab Emirates
[2] Khalifa Univ, Coll Med & Hlth Sci, Dept Pediat, Abu Dhabi, U Arab Emirates
[3] Khalifa Univ Sci & Technol, Healthcare Engn Innovat Ctr HEIC, Abu Dhabi, U Arab Emirates
[4] Khalifa Univ, Coll Arts & Sci, Dept Biol, Abu Dhabi, U Arab Emirates
[5] King Faisal Specialist Hosp & Res Ctr, Dept Comparat Med, Riyadh, Saudi Arabia
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
关键词
oocyte; sperm; embryo; RNA; oocyte activation; calcium; therapeutics; PHOSPHOLIPASE-C-ZETA; LIPID NANOPARTICLE FORMULATIONS; ZYGOTIC GENE ACTIVATION; MESOPOROUS SILICA NANOPARTICLES; FAILED OOCYTE ACTIVATION; TYROSINE KINASE PRESENT; DOMAIN-BINDING PROTEIN; SPERM PLC-ZETA; CA2+ OSCILLATIONS; EGG ACTIVATION;
D O I
10.3389/fcell.2023.1198848
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The recent COVID-19 pandemic led to many drastic changes in not only society, law, economics, but also in science and medicine, marking for the first time when drug regulatory authorities cleared for use mRNA-based vaccines in the fight against this outbreak. However, while indeed representing a novel application of such technology in the context of vaccination medicine, introducing RNA into cells to produce resultant molecules (proteins, antibodies, etc.) is not a novel principle. It has been common practice to introduce/inject mRNA into oocytes and embryos to inhibit, induce, and identify several factors in a research context, while such aspects have also been proposed as potential therapeutic and diagnostic applications to combat infertility in humans. Herein, we describe key areas where mRNA-based platforms have thus far represented potential areas of clinical applications, describing the advantages and limitations of such applications. Finally, we also discuss how recent advances in mRNA-based platforms, driven by the recent pandemic, may stand to benefit the treatment of infertility in humans. We also present brief future directions as to how we could utilise recent and current advancements to enhance RNA therapeutics within reproductive biology, specifically with relation to oocyte and embryo delivery.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] mRNA-based therapeutics–Advances and perspectives
    O. V. Sergeeva
    V. E. Koteliansky
    T. S. Zatsepin
    Biochemistry (Moscow), 2016, 81 : 709 - 722
  • [2] mRNA-based therapeutics-Advances and perspectives
    Sergeeva, O. V.
    Koteliansky, V. E.
    Zatsepin, T. S.
    BIOCHEMISTRY-MOSCOW, 2016, 81 (07) : 709 - 722
  • [3] mRNA-based cancer therapeutics
    Liu, Chuang
    Shi, Qiangqiang
    Huang, Xiangang
    Koo, Seyoung
    Kong, Na
    Tao, Wei
    NATURE REVIEWS CANCER, 2023, 23 (08) : 526 - 543
  • [4] mRNA-based cancer therapeutics
    Chuang Liu
    Qiangqiang Shi
    Xiangang Huang
    Seyoung Koo
    Na Kong
    Wei Tao
    Nature Reviews Cancer, 2023, 23 : 526 - 543
  • [5] Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
    Yang, Lizhi
    Li, Shuo
    Hou, Chao
    Wang, Zihua
    He, Wen
    Zhang, Wei
    NANOSCALE, 2025, 17 (07) : 3537 - 3548
  • [6] mRNA-Based Therapeutics in Cancer Treatment
    Sun, Han
    Zhang, Yu
    Wang, Ge
    Yang, Wen
    Xu, Yingjie
    PHARMACEUTICS, 2023, 15 (02)
  • [7] Development of mRNA-based therapeutics for proliferative vitreoretinopathy
    O'Hare, Michael
    Miller, William Phillip
    Arevalo-Alquichire, Said
    Rossin, Elizabeth J.
    Eliott, Dean
    Shu, Daisy Y.
    Rejman, Joanna
    Kim, Leo A.
    Arboleda-Velasquez, Joseph
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [8] Scaling for effective manufacturing of mRNA-based therapeutics
    Lee, Eunseo
    European Pharmaceutical Review, 2023, 28 (05): : 70 - 74
  • [9] mRNA-based therapeutics for mitochondrial optic neuropathies
    Lenaers, Guy
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [10] Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities
    Li, De-feng
    Liu, Qi-song
    Yang, Mei-feng
    Xu, Hao-ming
    Zhu, Min-zheng
    Zhang, Yuan
    Xu, Jing
    Tian, Cheng-mei
    Yao, Jun
    Wang, Li-sheng
    Liang, Yu-jie
    BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, 8 (03)