Preparation of Injectable Sodium Alginate/Platelet Rich Plasma Porous Microcarriers

被引：5

作者：

Hu, Hongbo ^{[1
]}

Zhou, Zhihua ^{[1
,2
]}

Liu, Wenjuan ^{[2
]}

Wu, Wei ^{[3
]}

Fang, Zemei ^{[1
]}

Gan, Yan ^{[1
]}

Fang, Jianjun ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan, Peoples R China

[2] Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat & Funct A, Xiangtan, Peoples R China

[3] Daqing Petrochem Res Inst CNPC, Daqing, Peoples R China

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS | 2023年 / 62卷 / 05期

关键词：

Sodium alginate; platelet rich plasma; porous microcarriers; ARTICULAR-CARTILAGE; IN-VITRO; MICROSPHERES; RELEASE; SCAFFOLDS; DEFECTS;

D O I：

10.1080/00222348.2023.2209378

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Porous sodium alginate/platelet rich plasma (SA/PRP) microcarriers were fabricated using an emulsion method combined with a freeze-drying method. The effects of the composition, concentration and freeze temperature on the properties of the porous microcarriers were studied. The optimum conditions for fabrication of the SA/PRP microcarriers were determined as -20 degrees C, SA concentration of 2.0 wt% and mass ratio of 2:1 (SA to PRP) for carrying cells. The SA/PRP microcarriers, with an average diameter of 100-350 mu m, showed an interconnective porous structure and the pore size was about 30-70 mu m. Such porous SA/PRP may be considered as a promising candidate for injectable carriers supporting attachment and proliferation of cells.

引用

页码：195 / 205

页数：11

共 33 条

[1] Biological Applications of Rare-Earth Based Nanoparticles [J].

Bouzigues, Cedric ;

Gacoin, Thierry ;

Alexandrou, Antigoni .

ACS NANO, 2011, 5 (11) :8488-8505

[2] Supporting Biomaterials for Articular Cartilage Repair [J].

Campos, Daniela Filipa Duarte ;

Drescher, Wolf ;

Rath, Bjoern ;

Tingart, Markus ;

Fischer, Horst .

CARTILAGE, 2012, 3 (03) :205-221

[3] Preparation and Properties of Sodium Alginate/Silk Fibroin Microcarriers [J].

Chen, Ping ;

Zhou, Zhihua ;

Liu, Wenjuan ;

Huang, Tianlong ;

Wu, Wei ;

Yi, Meiling ;

Zhang, Chao ;

He, Xiao ;

Fang, Jianjun .

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS, 2022, 61 (4-5) :636-648

[4] Microcarriers in application for cartilage tissue engineering: Recent progress and challenges [J].

Ding, Sheng-Long ;

Liu, Xin ;

Zhao, Xi-Yuan ;

Wang, Ke-Tao ;

Xiong, Wei ;

Gao, Zi-Li ;

Sun, Cheng-Yi ;

Jia, Min-Xuan ;

Li, Cheng ;

Gu, Qi ;

Zhang, Ming-Zhu .

BIOACTIVE MATERIALS, 2022, 17 :81-108

[5] Effect of platelet-rich plasma on the healing of intra-bony defects treated with a natural bone mineral and a collagen membrane [J].

Doeri, Ferenc ;

Huszar, Tamas ;

Nikolidakis, Dimitris ;

Arweiler, Nicole B. ;

Gera, Istvan ;

Sculean, Anton .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2007, 34 (03) :254-261

[6] Strontium mineralized silk fibroin porous microcarriers with enhanced osteogenesis as injectable bone tissue engineering vehicles [J].

Fang, Jianjun ;

Wang, Dan ;

Hu, FangFang ;

Li, Xinru ;

Zou, Xiaotong ;

Xie, Jinlu ;

Zhou, Zhihua .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2021, 128

[7] Sr-HA-graft-Poly(γ-benzyl-L-glutamate) Nanocomposite Microcarriers: Controllable Sr2+ Release for Accelerating Osteogenenisis and Bony Nonunion Repair [J].

Gao, Long ;

Huang, Zhongyue ;

Yan, Shifeng ;

Zhang, Kunxi ;

Xu, Shenghua ;

Li, Guifei ;

Cui, Lei ;

Yin, Jingbo .

BIOMACROMOLECULES, 2017, 18 (11) :3742-3752

[8] Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects [J].

Gentile, Pietro ;

Garcovich, Simone .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (04) :1-14

[9] A novel method for porosity measurement of various surface layers of nanofibers mat using image analysis for tissue engineering applications [J].

Ghasemi-Mobarakeh, L. ;

Semnani, D. ;

Morshed, M. .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 106 (04) :2536-2542

[10] Preparation and Properties of Poly(D,L-lacticie-co-glycolide- co-ε-caprolactone)/1,4-Butanendimine Modified Poly(lactide-co-glycolide) Blend Porous Microspheres [J].

Gu, Jiaming ;

Zhou, Zhihua ;

Huang, Tianlong ;

Wu, Wei ;

Liu, Wenjuan ;

Zhao, Yanmin ;

Chen, Ping ;

Zhou, Ziwei ;

Wang, Dan ;

Zhang, Chao ;

Yi, Meilin ;

He, Xiao ;

Fang, Jianjun .

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS, 2022, 61 (02) :270-280

← 1 2 3 4 →