Effects of hormones on intestinal stem cells

被引：8

作者：

Liu, Li ^{[1
]}

Zhang, Lilong ^{[1
]}

Li, Chunlei ^{[1
]}

Qiu, Zhendong ^{[1
]}

Kuang, Tianrui ^{[1
]}

Wu, Zhongkai ^{[1
]}

Deng, Wenhong ^{[1
]}

机构：

[1] Wuhan Univ, Dept Gen Surg, Renmin Hosp, Wuhan, Hubei, Peoples R China

来源：

STEM CELL RESEARCH & THERAPY | 2023年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Intestinal stem cells; Hormones; Stem cell; Therapy; GLUCAGON-LIKE PEPTIDE-2; THYROID-HORMONE; RECEPTOR-ALPHA; GASTROINTESTINAL HORMONES; ANDROGEN BIOSYNTHESIS; GASTRIC-CANCER; GROWTH; DIFFERENTIATION; EXPRESSION; PROMOTES;

D O I：

10.1186/s13287-023-03336-1

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute to the growth of intestinal tumours. Hormones, which are vital signalling agents in the body, have various effects on the growth and replacement of intestinal stem cells. This review summarises recent progress in the identification of hormones associated with intestinal stem cells. Several hormones, including thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone and progastrin, promote the development of intestinal stem cells. However, somatostatin and melatonin are two hormones that prevent the proliferation of intestinal stem cells. Therefore, new therapeutic targets for the diagnosis and treatment of intestinal illnesses can be identified by examining the impact of hormones on intestinal stem cells.

引用

页数：15

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