Evaluation of ABCG2-mediated extra-renal urate excretion in hemodialysis patients

被引：16

作者：

Ohashi, Yuki ^{[1
]}

Toyoda, Masao ^{[2
]}

Saito, Nobumichi ^{[2
]}

Koizumi, Masahiro ^{[2
]}

Kanai, Genta ^{[2
]}

Komaba, Hirotaka ^{[2
]}

Kimura, Moritsugu ^{[3
]}

Wada, Takehiko ^{[2
]}

Takahashi, Hiroo ^{[4
]}

Takahashi, Yuichiro ^{[4
]}

Ishida, Naoto ^{[5
]}

Kakuta, Takatoshi ^{[6
]}

Fukagawa, Masafumi ^{[2
]}

Ichida, Kimiyoshi ^{[1
,7
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Dept Pathophysiol, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan

[2] Tokai Univ, Dept Internal Med, Div Nephrol Endocrinol & Metab, Sch Med, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[3] Tokai Univ, Oiso Hosp, Div Nephrol Endocrinol & Metab, 21-1 Gakkyo, Oiso, Kanagawa 2590198, Japan

[4] Jinken Clin, 15-1 Ogi Cho, Ebina, Kanagawa 2430436, Japan

[5] Seichi Clin, 5-19-8 Numame, Isehara, Kanagawa 2591126, Japan

[6] Tokai Univ, Hachioji Hosp, Div Nephrol Endocrinol & Metab, 1838 Ishikawa Machi, Hachioji, Tokyo 1920032, Japan

[7] Jikei Univ, Sch Med, Dept Internal Med, Div Kidney & Hypertens,Minato Ku, 3-19-18 Shinbashi, Tokyo 1058471, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

RESISTANCE PROTEIN TRANSPORTER; URIC-ACID TRANSPORTERS; ABCG2; KIDNEY; EXPRESSION; METABOLISM; INTESTINE; LIVER;

D O I：

10.1038/s41598-022-26519-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two-thirds of urate is excreted via the renal pathway and the remaining one-third via the extra-renal pathway, the latter mainly via the intestine in healthy individuals. ABCG2, a urate exporter, is expressed in various tissues including the kidney and intestine, and its dysfunction leads to hyperuricemia and gout. ABCG2 is regarded as being responsible for most of the extra-renal urate excretion. However, the extra-renal urate excretion capacity via ABCG2 remains undefined in end-stage kidney diseases. Therefore, we evaluated the capacity of extra-renal ABCG2 using 123 anuric hemodialysis patients whose urate excretion depended on only the extra-renal pathway. ABCG2 function in each participant was estimated based on ABCG2 dysfunctional variants. We computed the uric acid pool (Pool(UA)) from bodyweight and serum urate level (SUA) using previously reported radio-isotopic data, and we analyzed the association between ABCG2 function and the Pool(UA). SUA and Pool(UA) increased significantly with ABCG2 dysfunction, and extra-renal ABCG2 could excrete up to approximately 60% of the daily uric acid turnover in hemodialysis patients. Our findings indicate that the extra-renal urate excretion capacity can expand with renal function decline and highlight that the extra-renal pathway is particularly important in the uric acid homeostasis for patients with renal dysfunction.

引用

页数：11

共 46 条

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