Insulin Resistance and Acne: The Role of Metformin as Alternative Therapy in Men

被引：13

作者：

Andreadi, Aikaterini ^{[1
,2
]}

Muscoli, Saverio ^{[3
]}

Tajmir, Rojin ^{[1
]}

Meloni, Marco ^{[1
,2
]}

Minasi, Alessandro ^{[2
]}

Muscoli, Carolina ^{[4
]}

Ilari, Sara ^{[4
]}

Mollace, Vincenzo ^{[4
]}

Della Morte, David ^{[1
,5
,6
]}

Bellia, Alfonso ^{[1
,2
]}

Campione, Elena ^{[1
,7
]}

Di Daniele, Nicola ^{[1
,5
]}

Lauro, Davide ^{[1
,2
]}

机构：

[1] Univ Roma Tor Vergata, Dept Syst Med, Sect Endocrinol & Metab Dis, I-00133 Rome, Italy

[2] Fdn Policlin Tor Vergata, Div Endocrinol & Diabetol, I-00133 Rome, Italy

[3] Fdn Policlin Tor Vergata, Div Cardiol, I-00133 Rome, Italy

[4] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy

[5] Fdn Policlin Tor Vergata, Dept Med Sci, Div Internal Med Hypertens, I-00133 Rome, Italy

[6] Univ Miami, Evelyn F McKnight Brain Inst, Dept Neurol, Miller Sch Med, 1120 NW 14th St, Miami, FL 33136 USA

[7] Fdn Policlin Tor Vergata, Unit Dermatol, I-00133 Rome, Italy

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 01期

关键词：

insulin resistance; metformin; acne; drug efficacy evaluation; GROWTH-FACTOR-I; INFLAMMATORY RESPONSE; SEBUM PRODUCTION; SEBACEOUS GLAND; GLYCEMIC-LOAD; 5-ALPHA-REDUCTASE; EXPRESSION; DIET; PATHOGENESIS; VULGARIS;

D O I：

10.3390/ph16010027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The association between acne and insulin resistance has not been investigated as thoroughly in males as it has been in women, despite the fact that in adult men, acne prevalence has grown. On the face, sebaceous glands produce and secrete sebum, which lubricates the skin and protects it from friction. Metformin, an insulin-sensitizing medication, may modify the association between acne vulgaris and insulin resistance (IR). Individuals with IR, metabolic syndrome or with impaired glucose tolerance are sometimes treated 'off label' with Metformin. In these conditions, IR may be a leading factor in the pathogenesis of acne, and in men, Metformin treatment may reduce the Global Acne Grading System (GAGS) score by enhancing insulin sensitivity. However, additional clinical studies are required to corroborate these assumptions.

引用

页数：11

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