Neural attenuation: age-related dedifferentiation in the left occipitotemporal cortex for visual word processing

被引：1
|
作者：
Xue, Licheng [1 ,2 ]
Lv, Yating [3 ,4 ,5 ,6 ]
Zhao, Jing [1 ,5 ,6 ]
机构：
[1] Hangzhou Normal Univ, Jing Hengyi Sch Educ, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[2] South China Normal Univ, Inst Brain Res & Rehabil, 55 Zhongshan Ave West Rd, Guangzhou 510631, Peoples R China
[3] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Affiliated Hosp, 126 Wenzhou Rd, Hangzhou 311121, Peoples R China
[4] Hangzhou Normal Univ, Inst Psychol Sci, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[5] Zhejiang Key Lab Res Assessment Cognit Impairments, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[6] 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
来源：
CEREBRAL CORTEX | 2023年 / 33卷 / 10期
基金：
美国国家科学基金会;
关键词：
the left vOT; attenuation; neural dedifferentiation; aging; visual word processing; OF-THE-TONGUE; FORM AREA; LANGUAGE; BRAIN; FMRI; RECOGNITION; SPECIALIZATION; CONNECTIVITY; SENSITIVITY; SELECTIVITY;
D O I：
10.1093/cercor/bhac488
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study investigated the age-related neural basis of cognitive decline in the left ventral occipitotemporal cortex (vOT)-a brain area that responds selectively to visual words processing. Functional magnetic resonance imaging was used to estimate neural activity in this area, while young and old adults viewed words and line drawings. Our results demonstrated the existence of neural dedifferentiation of the left vOT in old adults during visual word processing. More specifically, this dedifferentiation was due to neural attenuation that is, decreased response to words rather than increased response to line drawings in old adults compared with young adults. In addition, individuals who showed decreased neural response to words had worse performance in visual word processing. Taken together, our findings support the neural attenuation hypothesis for the cognitive decline in visual word processing in old adults.
引用
收藏
页码：6111 / 6119
页数：9
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