Neural attenuation: age-related dedifferentiation in the left occipitotemporal cortex for visual word processing

被引：1
|
作者：
Xue, Licheng [1 ,2 ]
Lv, Yating [3 ,4 ,5 ,6 ]
Zhao, Jing [1 ,5 ,6 ]
机构：
[1] Hangzhou Normal Univ, Jing Hengyi Sch Educ, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[2] South China Normal Univ, Inst Brain Res & Rehabil, 55 Zhongshan Ave West Rd, Guangzhou 510631, Peoples R China
[3] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Affiliated Hosp, 126 Wenzhou Rd, Hangzhou 311121, Peoples R China
[4] Hangzhou Normal Univ, Inst Psychol Sci, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[5] Zhejiang Key Lab Res Assessment Cognit Impairments, 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
[6] 2318 Yuhangtang Rd, Hangzhou 311121, Peoples R China
来源：
CEREBRAL CORTEX | 2023年 / 33卷 / 10期
基金：
美国国家科学基金会;
关键词：
the left vOT; attenuation; neural dedifferentiation; aging; visual word processing; OF-THE-TONGUE; FORM AREA; LANGUAGE; BRAIN; FMRI; RECOGNITION; SPECIALIZATION; CONNECTIVITY; SENSITIVITY; SELECTIVITY;
D O I：
10.1093/cercor/bhac488
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study investigated the age-related neural basis of cognitive decline in the left ventral occipitotemporal cortex (vOT)-a brain area that responds selectively to visual words processing. Functional magnetic resonance imaging was used to estimate neural activity in this area, while young and old adults viewed words and line drawings. Our results demonstrated the existence of neural dedifferentiation of the left vOT in old adults during visual word processing. More specifically, this dedifferentiation was due to neural attenuation that is, decreased response to words rather than increased response to line drawings in old adults compared with young adults. In addition, individuals who showed decreased neural response to words had worse performance in visual word processing. Taken together, our findings support the neural attenuation hypothesis for the cognitive decline in visual word processing in old adults.
引用
收藏
页码：6111 / 6119
页数：9
相关论文
共 50 条
  • [21] Age Differences In Retrieval-Related Reinstatement Reflect Age-Related Dedifferentiation At Encoding
    Hill, Paul F.
    King, Danielle R.
    Rugg, Michael D.
    CEREBRAL CORTEX, 2021, 31 (01) : 106 - 122
  • [22] The effect of hearing loss on age-related differences in neural distinctiveness
    Guerreiro, Maria J. S.
    Puschmann, Sebastian
    Eck, Judith
    Rienacker, Franziska
    Van Gerven, Pascal W. M.
    Thiel, Christiane M.
    AGING NEUROPSYCHOLOGY AND COGNITION, 2024, 31 (04) : 627 - 645
  • [23] Neural correlates of age-related decline and compensation in visual attention capacity
    Wiegand, Iris
    Toellner, Thomas
    Dyrholm, Mads
    Mueller, Hermann J.
    Bundesen, Claus
    Finke, Kathrin
    NEUROBIOLOGY OF AGING, 2014, 35 (09) : 2161 - 2173
  • [24] Age-related differences in the processing of redundant visual dimensions
    Bucur, B
    Madden, DJ
    Allen, PA
    PSYCHOLOGY AND AGING, 2005, 20 (03) : 435 - 446
  • [25] Age-related neural differences in affiliation and isolation
    Beadle, Janelle N.
    Yoon, Carolyn
    Gutchess, Angela H.
    COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 2012, 12 (02) : 269 - 279
  • [26] The neural-vascular basis of age-related processing speed decline
    Zhao, Yuguang
    Liu, Peiying
    Turner, Monroe P.
    Abdelkarim, Dema
    Lu, Hanzhang
    Rypma, Bart
    PSYCHOPHYSIOLOGY, 2021, 58 (07)
  • [27] GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness
    Chamberlain, Jordan D.
    Gagnon, Holly
    Lalwani, Poortata
    Cassady, Kaitlin E.
    Simmonite, Molly
    Seidler, Rachael D.
    Taylor, Stephan F.
    Weissman, Daniel H.
    Park, Denise C.
    Polk, Thad A.
    NEUROBIOLOGY OF AGING, 2021, 102 : 170 - 177
  • [28] Age-related temporal processing speed deterioration in auditory cortex
    Mendelson, JR
    Ricketts, C
    HEARING RESEARCH, 2001, 158 (1-2) : 84 - 94
  • [29] Resting state neural networks for visual Chinese word processing in Chinese adults and children
    Li, Ling
    Liu, Jiangang
    Chen, Feiyan
    Feng, Lu
    Li, Hong
    Tian, Jie
    Lee, Kang
    NEUROPSYCHOLOGIA, 2013, 51 (08) : 1571 - 1583
  • [30] Dissociating the functions of superior and inferior parts of the left ventral occipito-temporal cortex during visual word and object processing
    Ludersdorfer, Philipp
    Price, Cathy J.
    Duncan, Keith J. Kawabata
    DeDuck, Kristina
    Neufeld, Nicholas H.
    Seghier, Mohamed L.
    NEUROIMAGE, 2019, 199 : 325 - 335
12345