A new strategy for direct solution electrospinning of phosphorylated poly (vinyl chloride)/polyethyleneimine blend in alcohol media

被引:18
作者
Altinkok, Cagatay [1 ]
Sagdic, Gokhan [1 ]
Daglar, Ozgun [1 ]
Ayra, Merve Ercan [2 ]
Durmaz, Yasemin Yuksel [2 ,3 ]
Durmaz, Hakan [1 ]
Acik, Gokhan [4 ]
机构
[1] Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkiye
[2] Istanbul Medipol Univ, Sch Engn & Nat Sci, Dept Biomed Engn, TR-34810 Istanbul, Turkiye
[3] Istanbul Medipol Univ, Res Inst Hlth Sci & Technol SABITA, TR-34810 Istanbul, Turkiye
[4] Trakya Univ, Arda Vocat Sch, Dept Chem & Chem Proc Technol, TR-39100 Edirne, Turkiye
关键词
Blood-contacting; Electrospinning; Metal-freeazide-alkyne 13-dipolar cycloaddi-tion; Poly (vinyl chloride); Polyethyleneimine; POLY(VINYL CHLORIDE); POLYETHYLENEIMINE; NANOFIBERS; NANOPARTICLES; PVC; POLY(ETHYLENEIMINE); IMMOBILIZATION; FABRICATION; PARTICLES; MEMBRANES;
D O I
10.1016/j.eurpolymj.2022.111750
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Phosphorylated poly(vinyl chloride) (PPVC)/polyethyleneimine (PEI)-based nanofibers were produced via electrospinning in their blended solutions for the first time. For this purpose, PVC was partially converted into PVC-N3 and the PVC-N3 is then reacted with bis(diethoxyphosphoryl) acetylene (BDPA) via metal-free azide--alkyne 1,3-dipolar cycloaddition reaction to achieve the alcohol-soluble PPVC. PPVC and PEI solutions at certain concentrations prepared in methanol were electrospun from a single syringe at 90/10 and 85/15 vol ratios without phase separation. The accuracy of the modifications conducted on PVC was proven by Fourier-transform infrared (FT-IR), proton and carbon nuclear magnetic resonance (1H NMR and 13C NMR) spectros-copies and gel permeation chromatography (GPC), respectively. The achieved nanofibers and their intermediates were characterized by scanning electron microscope (SEM), water contact angle (WCA) measurement, ther-mogravimetric (TGA) and differential scanning calorimetry (DSC) analyses.The blood interaction of PPVC-PEI was evaluated through hemolysis and platelet activation assay, since most of the biomedical applications of PVC derivatives have close contact with blood. The results showed that PPVC-PEI nanofibers provide a safer surface for platelet with lower hemolytic activity compared to PPVC nanofibers. Therefore, PPVC-PEI-based electrospun nanofibers obtained by such an effective strategy exhibited a promising perspective for scientists in various biomedical purposes.
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页数:10
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