Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles

被引：11

作者：

Monroe, Maya K. ^{[1
,2
]}

Wang, Han ^{[1
,2
]}

Anderson, Caleb F. ^{[1
,2
]}

Qin, Meng ^{[1
,2
]}

Thio, Chloe L. ^{[3
]}

Flexner, Charles ^{[4
]}

Cui, Honggang ^{[1
,2
,5
,6
,7
]}

机构：

[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Div Clin Pharmacol & Infect Dis, Sch Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[6] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Sch Med, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Wilmer Eye Inst, Ctr Nanomed, Sch Med, Baltimore, MD 21287 USA

来源：

BIOMATERIALS SCIENCE | 2023年 / 11卷 / 02期

关键词：

DRUG-DELIVERY; NANOSTRUCTURED HYDROGELS; RESPONSIVE HYDROGELS; CONTROLLED-RELEASE; RATIONAL DESIGN; PREVENTION; NANOFIBERS; ENCAPSULATION; PROPENSITIES; DOXORUBICIN;

D O I：

10.1039/d2bm01649d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The development of long-acting antiviral therapeutic delivery systems is crucial to improve the current treatment and prevention of HIV and chronic HBV. We report here on the conjugation of tenofovir (TFV), an FDA approved nucleotide reverse transcriptase inhibitor (NRTI), to rationally designed peptide amphiphiles (PAs), to construct antiviral prodrug hydrogelators (TFV-PAs). The resultant conjugates can self-assemble into one-dimensional nanostructures in aqueous environments and consequently undergo rapid gelation upon injection into 1x PBS solution to create a drug depot. The TFV-PA designs containing two or three valines could attain instantaneous gelation, with one displaying sustained release for more than 28 days in vitro. Our studies suggest that minor changes in peptide design can result in differences in supramolecular morphology and structural stability, which impacted in vitro gelation and release. We envision the use of this system as an important delivery platform for the sustained, linear release of TFV at rates that can be precisely tuned to attain therapeutically relevant TFV plasma concentrations.

引用

页码：489 / 498

页数：10

共 102 条

[11] Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering [J].

Chakroun, Rami W. ;

Wang, Feihu ;

Lin, Ran ;

Wang, Yin ;

Su, Hao ;

Pompa, Danielle ;

Cui, Honggang .

ACS NANO, 2019, 13 (07) :7780-7790

[12] Self-assembling prodrugs [J].

Cheetham, Andrew G. ;

Chakroun, Rami W. ;

Ma, Wang ;

Cui, Honggang .

CHEMICAL SOCIETY REVIEWS, 2017, 46 (21) :6638-6663

[13] Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles [J].

Cheetham, Andrew G. ;

Ou, Yu-Chuan ;

Zhang, Pengcheng ;

Cui, Honggang .

CHEMICAL COMMUNICATIONS, 2014, 50 (45) :6039-6042

[14] Supramolecular Nanostructures Formed by Anticancer Drug Assembly [J].

Cheetham, Andrew G. ;

Zhang, Pengcheng ;

Lin, Yi-an ;

Lock, Lye Lin ;

Cui, Honggang .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (08) :2907-2910

[15] Controlled release of free doxorubicin from peptide-drug conjugates by drug loading [J].

Chen, Zhipeng ;

Zhang, Pengcheng ;

Cheetham, Andrew G. ;

Moon, Jae Hyon ;

Moxley, James W., Jr. ;

Lin, Yi-an ;

Cui, Honggang .

JOURNAL OF CONTROLLED RELEASE, 2014, 191 :123-130

[16] Are Patients and Their Providers Talking About Long-Acting Injectable Antiretroviral Therapy? Penetration into Clinical Encounters at Three US Care Sites [J].

Christopoulos, Katerina A. ;

Colasanti, Jonathan ;

Johnson, Mallory O. ;

Tsuzuki, Manami Diaz ;

Erguera, Xavier A. ;

Flores, Rey ;

Kerman, Jared ;

Dance, Kaylin ;

Sauceda, John A. ;

Neilands, Torsten B. ;

Dilworth, Samantha E. ;

Koester, Kimberly A. ;

Gutierrez, Jose ;

Schneider, John A. ;

Montgomery, Elizabeth ;

McNulty, Moira C. .

OPEN FORUM INFECTIOUS DISEASES, 2022, 9 (07)

[17] Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels [J].

Cinar, Goksu ;

Ozdemir, Ayse ;

Hamsici, Seren ;

Gunay, Gokhan ;

Dana, Aykutlu ;

Tekinay, Ayse B. ;

Guler, Mustafa O. .

BIOMATERIALS SCIENCE, 2017, 5 (01) :67-76

[18] Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles [J].

Cobb, Denise A. ;

Smith, Nathan ;

Deodhar, Suyash ;

Bade, Aditya N. ;

Gautam, Nagsen ;

Shetty, Bhagya Laxmi Dyavar ;

McMillan, JoEllyn ;

Alnouti, Yazen ;

Cohen, Samuel M. ;

Gendelman, Howard E. ;

Edagwa, Benson .

NATURE COMMUNICATIONS, 2021, 12 (01)

[19] Amino Acid Sequence in Constitutionally Isomeric Tetrapeptide Amphiphiles Dictates Architecture of One-Dimensional Nanostructures [J].

Cui, Honggang ;

Cheetham, Andrew G. ;

Pashuck, E. Thomas ;

Stupp, Samuel I. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (35) :12461-12468

[20] Self-Assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials [J].

Cui, Honggang ;

Webber, Matthew J. ;

Stupp, Samuel I. .

BIOPOLYMERS, 2010, 94 (01) :1-18

← 1 2 3 4 5 6 7 8 9 10 →