John squire and endothelial glycocalyx structure: an unfinished story

被引:3
作者
Arkill, Kenton P. [1 ]
Michel, C. Charles [2 ]
Rider, Elizabeth V. M. [1 ]
Wood, Elise A. [1 ]
Small, Mathew O. [1 ]
Brown, Jennifer L. E. [1 ]
Kinnaird, Abigail L. [1 ]
机构
[1] Univ Nottingham, Sch Med, Biodiscovery Inst, Nottingham, England
[2] Imperial Coll London, Dept Bioengn, London, England
基金
英国医学研究理事会;
关键词
Vascular permeability; Reflection coefficient; Albumin; Proteoglycan; Glycosaminoglycan; CATIONIZED FERRITIN; BLOOD CAPILLARIES; OSMOTIC FLOW; TRANSPORT; ORGANIZATION; MECHANISM; VESICLES; ALBUMIN; SURFACE; WALLS;
D O I
10.1007/s10974-022-09629-x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.
引用
收藏
页码:217 / 223
页数:7
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