Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases

被引：20

作者：

Shi, Wenjia ^{[1
]}

Tan, Cheng ^{[1
]}

Liu, Can ^{[1
]}

Chen, Dan ^{[1
]}

机构：

[1] Cent South Univ, Sch Basic Med Sci, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2023年 / 34卷 / 03期

关键词：

Drp1; Fis1; mitochondrial dynamics; neurodegenerative diseases; pathological fission; physiological fission; DYNAMIN-RELATED PROTEIN-1; DEFECTIVE AXONAL-TRANSPORT; S-NITROSYLATION; SYNAPTIC DAMAGE; ISCHEMIA/REPERFUSION INJURY; ENDOPLASMIC-RETICULUM; DRP1; PHOSPHORYLATION; ABNORMAL INTERACTION; THERAPEUTIC TARGETS; AMYLOID-BETA;

D O I：

10.1515/revneuro-2022-0056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.

引用

页码：275 / 294

页数：20

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