Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases

被引：20
作者：
Shi, Wenjia [1 ]
Tan, Cheng [1 ]
Liu, Can [1 ]
Chen, Dan [1 ]
机构：
[1] Cent South Univ, Sch Basic Med Sci, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China
来源：
REVIEWS IN THE NEUROSCIENCES | 2023年 / 34卷 / 03期
关键词：
Drp1; Fis1; mitochondrial dynamics; neurodegenerative diseases; pathological fission; physiological fission; DYNAMIN-RELATED PROTEIN-1; DEFECTIVE AXONAL-TRANSPORT; S-NITROSYLATION; SYNAPTIC DAMAGE; ISCHEMIA/REPERFUSION INJURY; ENDOPLASMIC-RETICULUM; DRP1; PHOSPHORYLATION; ABNORMAL INTERACTION; THERAPEUTIC TARGETS; AMYLOID-BETA;
D O I：
10.1515/revneuro-2022-0056
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.
引用
收藏
页码：275 / 294
页数：20
相关论文
共 50 条
[21]   Structural basis for recruitment of mitochondrial fission complexes by Fis1 [J].
Zhang, Yan ;
Chan, David C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) :18526-18530
[22]   Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation-induced apoptosis [J].
Zhang, Zhenzhen ;
Liu, Lei ;
Wu, Shengnan ;
Xing, Da .
FASEB JOURNAL, 2016, 30 (01) :466-476
[23]   Allosteric Modulation of Drp1 Mechanoenzyme Assembly and Mitochondrial Fission by the Variable Domain [J].
Strack, Stefan ;
Cribbs, J. Thomas .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (14) :10990-11001
[24]   Targeting Drp1 and mitochondrial fission for therapeutic immune modulation [J].
Simula, Luca ;
Campanella, Michelangelo ;
Campello, Silvia .
PHARMACOLOGICAL RESEARCH, 2019, 146
[25]   PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons [J].
Lee, Duk-shin ;
Kim, Ji-Eun .
CELL DEATH & DISEASE, 2018, 9
[26]   Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation [J].
Krzystek, Thomas J. ;
Banerjee, Rupkatha ;
Thurston, Layne ;
Huang, JianQiao ;
Swinter, Kelsey ;
Rahman, Saad Navid ;
Falzone, Tomas L. ;
Gunawardena, Shermali .
CELL DEATH & DISEASE, 2021, 12 (09)
[27]   Numb Depletion Promotes Drp1-Mediated Mitochondrial Fission and Exacerbates Mitochondrial Fragmentation and Dysfunction in Acute Kidney Injury [J].
Liu, Ze ;
Li, Hao ;
Su, Jianqun ;
Xu, Shihui ;
Zhu, Fengxin ;
Ai, Jun ;
Hu, Zheng ;
Zhou, Miaomiao ;
Tian, Jianwei ;
Su, Zhiyuan ;
Yang, Peiliang ;
Nie, Jing .
ANTIOXIDANTS & REDOX SIGNALING, 2019, 30 (15) :1797-1816
[28]   Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes [J].
Grel, Hubert ;
Woznica, Damian ;
Ratajczak, Katarzyna ;
Kalwarczyk, Ewelina ;
Anchimowicz, Julia ;
Switlik, Weronika ;
Olejnik, Piotr ;
Zielonka, Piotr ;
Stobiecka, Magdalena ;
Jakiela, Slawomir .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (17)
[29]   RhoA/ROCK Signaling Regulates Drp1-Mediated Mitochondrial Fission During Collective Cell Migration [J].
Qu, Chen ;
Yang, Wen ;
Kan, Yating ;
Zuo, Hui ;
Wu, Mengqi ;
Zhang, Qing ;
Wang, Heng ;
Wang, Dou ;
Chen, Jiong .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[30]   Pharmacological Activation of AMPK Prevents Drp1-mediated Mitochondrial Fission and Alleviates Hepatic Steatosis In vitro [J].
Du, Jingxia ;
Wang, Tingting ;
Xiao, Chengyao ;
Dong, Yibo ;
Zhou, Shiyao ;
Zhu, Yujiao .
CURRENT MOLECULAR MEDICINE, 2024, 24 (12) :1506-1517
12345