Metagenomic next-generation sequencing on bronchoalveolar lavage fluid to contribute to diagnosis of subclinical pulmonary tuberculosis with scarce sputum and negative smear in a patient mimicking adult- onset still's disease: A case report

被引:0
|
作者
Guan, Yanchun [1 ]
Ma, Xiao [2 ]
Sun, Xiangnan [1 ]
Zhang, Hongfeng [1 ]
机构
[1] Dalian Med Univ, Affiliated Hosp 1, Dept Rheumatol, Zhongshan Rd 222, Dalian 116011, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dept Anesthesia, Dalian, Peoples R China
基金
美国国家科学基金会;
关键词
Metagenomic next -generation sequencing; Adult -onset still 's disease; Tuberculosis; Ferritin; T-SPOT.TB;
D O I
10.1016/j.diagmicrobio.2023.116165
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Extremely high serum ferritin, which is regarded as a marker of adult-onset still's disease (AOSD), has been rarely observed in patients with TB. We report a case of TB diagnose by metagenomic next-generation sequencing (mNGS) who presented with clinical criteria of AOSD and extreme hyperferritinemia, which posed a diagnostic confusion. TB presenting with major clinical criteria of AOSD should be notable. Since TB remains a potentially curable disease, an awareness of its' protean manifestations is essential. A typical or even normal outcomes of clinical, microbiochemical, and radiologic evaluation should not be overlooked and dedicated diagnostic workup should be performed for TB diagnosis. For equivocal cases, mNGS could be helpful.
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页数:5
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