The relationship between TGF-β1 and cognitive function in the brain

被引：10
作者：
Su, Chen [1 ]
Miao, Jie [1 ]
Guo, Junhong [1 ]
机构：
[1] Shanxi Med Univ, Dept Neurol, Hosp 1, Taiyuan 030000, Shanxi, Peoples R China
来源：
BRAIN RESEARCH BULLETIN | 2023年 / 205卷
关键词：
TGF-beta; 1; Cognition; Synapses; Neurovascular unit; Neurological diseases; GROWTH-FACTOR-BETA; SMALL-VESSEL DISEASE; TGF-BETA; ALZHEIMERS-DISEASE; TRANSFORMING GROWTH-FACTOR-BETA-1; INTRACELLULAR DOMAIN; SYNAPTIC PLASTICITY; TRANSGENIC MICE; GENE-THERAPY; L-CARNOSINE;
D O I：
10.1016/j.brainresbull.2023.110820
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Transforming growth factor-beta 1 (TGF-beta 1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-beta 1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-beta 1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-beta 1 influences cognitive function and to explore thera-peutic avenues for targeting TGF-beta 1 in neurodegenerative conditions. This investigation sheds light on TGF-beta 1's contribution to cognitive function and offers prospects for innovative treatments and interventions. This review delves into the intricate relationship between TGF-beta 1 and cognitive function.
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页数：12
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