Non-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy response

被引：9

作者：

Hashemi, Mehrdad ^{[1
,2
]}

Daneii, Pouria ^{[1
]}

Zandieh, Mohammad Arad ^{[3
]}

Raesi, Rasoul ^{[4
,5
]}

Zahmatkesh, Neda ^{[6
]}

Bayat, Mehrsa ^{[7
]}

Abuelrub, Anwar ^{[8
]}

Koohpar, Zeinab Khazaei ^{[9
]}

Aref, Amir Reza ^{[10
]}

Zarrabi, Ali ^{[11
]}

Rashidi, Mohsen ^{[12
,13
]}

Salimimoghadam, Shokooh ^{[14
]}

Entezari, Maliheh ^{[1
,2
]}

Taheriazam, Afshin ^{[1
,15
]}

Khorrami, Ramin ^{[16
]}

机构：

[1] Islamic Azad Univ, Farhikhtegan Hosp Tehran Med Sci, Farhikhtegan Med Convergence Sci Res Ctr, Tehran, Iran

[2] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[3] Univ Tehran, Fac Vet Med, Dept Food Hyg & Qual Control, Div Epidemiol, Tehran, Iran

[4] Mashhad Univ Med Sci, Dept Hlth Serv Management, Mashhad, Iran

[5] Mashhad Univ Med Sci, Dept Med Surg Nursing, Mashhad, Iran

[6] Islamic Azad Univ, Dept Genet, Zanjan Branch, Zanjan, Iran

[7] Bahcesehir Univ, Dept Hlth Sci, Istanbul, Turkiye

[8] Bahcesehir Univ, Hlth Sci Inst, Neurosci Lab, Istanbul, Turkiye

[9] Islamic Azad Univ, Fac Biol Sci, Dept Cell & Mol Biol, Tonekabon Branch, Tonekabon, Iran

[10] Harvard Med Sch, Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA USA

[11] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye

[12] Mazandaran Univ Med Sci, Fac Med, Dept Pharmacol, Sari, Iran

[13] Mazandaran Univ Med Sci, Hlth Plant & Livestock Prod Res Ctr, Sari, Iran

[14] Shahid Chamran Univ Ahvaz, Fac Vet Med, Dept Biochem & Mol Biol, Ahvaz, Iran

[15] Islamic Azad Univ, Fac Med, Dept Orthoped, Tehran Med Sci, Tehran, Iran

[16] Univ Tehran, Fac Vet Med, Dept Food Hyg & Qual Control, Tehran, Iran

来源：

NON-CODING RNA RESEARCH | 2024年 / 9卷 / 01期

关键词：

m6A; Cancer; miRNA; lncRNA; circRNA; Immune response; CELL LUNG-CANCER; MESSENGER-RNA; NUCLEAR-RNA; M(6)A RNA; HEPATOCELLULAR-CARCINOMA; COMPREHENSIVE ANALYSIS; MALIGNANT PROGRESSION; CISPLATIN RESISTANCE; COLORECTAL-CANCER; IMMUNE ESCAPE;

D O I：

10.1016/j.ncrna.2023.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence of RNA modifications has recently been considered as critical post-transcriptional regulations which governed gene expression. N6-methyladenosine (m6A) modification is the most abundant type of RNA modification which is mediated by three distinct classes of proteins called m6A writers, readers, and erasers. Accumulating evidence has been made in understanding the role of m6A modification of non-coding RNAs (ncRNAs) in cancer. Importantly, aberrant expression of ncRNAs and m6A regulators has been elucidated in various cancers. As the key role of ncRNAs in regulation of cancer hallmarks is well accepted now, it could be accepted that m6A modification of ncRNAs could affect cancer progression. The present review intended to discuss the latest knowledge and importance of m6A epigenetic regulation of ncRNAs including mircoRNAs, long non-coding RNAs, and circular RNAs, and their interaction in the context of cancer. Moreover, the current insight into the underlying mechanisms of therapy resistance and also immune response and escape mediated by m6A regulators and ncRNAs are discussed.

引用

页码：84 / 104

页数：21

共 311 条

[1] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].