Neoadjuvant immune checkpoint blockade: A window of opportunity to advance cancer immunotherapy

被引：143

作者：

Topalian, Suzanne L. ^{[1
,3
,4
]}

Forde, Patrick M. ^{[2
,3
,4
]}

Emens, Leisha A. ^{[5
]}

Yarchoan, Mark ^{[2
,3
,4
]}

Smith, Kellie N. ^{[2
,3
,4
]}

Pardoll, Drew M. ^{[2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Sch Med, Baltimore, MD 21287 USA

[5] Ankyra Therapeut, Cambridge, MA 02142 USA

来源：

CANCER CELL | 2023年 / 41卷 / 09期

关键词：

RESECTABLE HEPATOCELLULAR-CARCINOMA; PEMBROLIZUMAB PLUS CHEMOTHERAPY; OPEN-LABEL; LUNG-CANCER; STAGE-III; MISMATCH REPAIR; PD-1; BLOCKADE; OPACIN-NEO; HIGH-RISK; NIVOLUMAB;

D O I：

10.1016/j.ccell.2023.07.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among new treatment approaches for patients with cancer, few have accelerated as quickly as neoadjuvant immune checkpoint blockade (ICB). Neoadjuvant cancer therapy is administered before curative-intent surgery in treatment-naive patients. Conventional neoadjuvant chemotherapy and radiotherapy are primarily intended to reduce tumor size, improving surgical resectability. However, recent scientific evidence outlined here suggests that neoadjuvant immunotherapy can expand and transcriptionally modify tumor-specific T cell clones to enhance both intratumoral and systemic anti-tumor immunity. It further offers a unique "window of opportunity"to explore mechanisms and identify novel biomarkers of ICB response and resistance, opening possibilities for refining long-term clinical outcome predictions and developing new, more highly effective ICB combination therapies. Here, we examine advances in clinical and scientific knowledge gleaned from studies in select cancers and describe emerging key principles relevant to neoadjuvant ICB across many cancer types.

引用

页码：1551 / 1566

页数：16

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